Next Article in Journal
Effect of Metals on Kinetic Pathways of Amyloid-β Aggregation
Next Article in Special Issue
Analysis of Guanine Oxidation Products in Double-Stranded DNA and Proposed Guanine Oxidation Pathways in Single-Stranded, Double-Stranded or Quadruplex DNA
Previous Article in Journal
A Firefly-Inspired Method for Protein Structure Prediction in Lattice Models
Previous Article in Special Issue
Control of Cell Differentiation by Mitochondria, Typically Evidenced in Dictyostelium Development
Article Menu

Export Article

Open AccessReview
Biomolecules 2014, 4(1), 76-100;

Long Noncoding RNAs in Imprinting and X Chromosome Inactivation

Department of Genetics and Developmental Biology, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030, USA
Author to whom correspondence should be addressed.
Received: 25 November 2013 / Revised: 18 December 2013 / Accepted: 27 December 2013 / Published: 7 January 2014
(This article belongs to the Special Issue Focus Update in Biomolecules)
Full-Text   |   PDF [569 KB, uploaded 7 January 2014]   |  


The field of long noncoding RNA (lncRNA) research has been rapidly advancing in recent years. Technological advancements and deep-sequencing of the transcriptome have facilitated the identification of numerous new lncRNAs, many with unusual properties, however, the function of most of these molecules is still largely unknown. Some evidence suggests that several of these lncRNAs may regulate their own transcription in cis, and that of nearby genes, by recruiting remodeling factors to local chromatin. Notably, lncRNAs are known to exist at many imprinted gene clusters. Genomic imprinting is a complex and highly regulated process resulting in the monoallelic silencing of certain genes, based on the parent-of-origin of the allele. It is thought that lncRNAs may regulate many imprinted loci, however, the mechanism by which they exert such influence is poorly understood. This review will discuss what is known about the lncRNAs of major imprinted loci, and the roles they play in the regulation of imprinting. View Full-Text
Keywords: imprinting; long noncoding RNA; XIST; KCNQOT1; Igf2r; Airn; SNURF-SNRPN; UBE3A; DLK1-DIO3; H19-IGF2 imprinting; long noncoding RNA; XIST; KCNQOT1; Igf2r; Airn; SNURF-SNRPN; UBE3A; DLK1-DIO3; H19-IGF2

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Autuoro, J.M.; Pirnie, S.P.; Carmichael, G.G. Long Noncoding RNAs in Imprinting and X Chromosome Inactivation. Biomolecules 2014, 4, 76-100.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top