Next Article in Journal / Special Issue
Role of the Checkpoint Clamp in DNA Damage Response
Previous Article in Journal
Comparative Ultrastructure and Carbohydrate Composition of Gastroliths from Astacidae, Cambaridae and Parastacidae Freshwater Crayfish (Crustacea, Decapoda)
Previous Article in Special Issue
Molecular Insights into Poly(ADP-ribose) Recognition and Processing
Open AccessReview

Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery

Institut Curie, Centre de Recherche, CNRS, UMR3348, Centre Universitaire, Bat110, 91405, Orsay, France
*
Author to whom correspondence should be addressed.
Biomolecules 2013, 3(1), 39-71; https://doi.org/10.3390/biom3010039
Received: 30 October 2012 / Revised: 11 December 2012 / Accepted: 11 December 2012 / Published: 27 December 2012
(This article belongs to the Special Issue DNA Damage Response)
Homologous recombination is a universal mechanism that allows DNA repair and ensures the efficiency of DNA replication. The substrate initiating the process of homologous recombination is a single-stranded DNA that promotes a strand exchange reaction resulting in a genetic exchange that promotes genetic diversity and DNA repair. The molecular mechanisms by which homologous recombination repairs a double-strand break have been extensively studied and are now well characterized. However, the mechanisms by which homologous recombination contribute to DNA replication in eukaryotes remains poorly understood. Studies in bacteria have identified multiple roles for the machinery of homologous recombination at replication forks. Here, we review our understanding of the molecular pathways involving the homologous recombination machinery to support the robustness of DNA replication. In addition to its role in fork-recovery and in rebuilding a functional replication fork apparatus, homologous recombination may also act as a fork-protection mechanism. We discuss that some of the fork-escort functions of homologous recombination might be achieved by loading of the recombination machinery at inactivated forks without a need for a strand exchange step; as well as the consequence of such a model for the stability of eukaryotic genomes. View Full-Text
Keywords: homologous recombination; DNA replication; DNA repair; fork-restart; fork-repair; fork stabilization homologous recombination; DNA replication; DNA repair; fork-restart; fork-repair; fork stabilization
Show Figures

Figure 1

MDPI and ACS Style

Costes, A.; Lambert, S.A.E. Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery. Biomolecules 2013, 3, 39-71. https://doi.org/10.3390/biom3010039

AMA Style

Costes A, Lambert SAE. Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery. Biomolecules. 2013; 3(1):39-71. https://doi.org/10.3390/biom3010039

Chicago/Turabian Style

Costes, Audrey; Lambert, Sarah A.E. 2013. "Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery" Biomolecules 3, no. 1: 39-71. https://doi.org/10.3390/biom3010039

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop