Next Article in Journal
Utilizing Feature Selection Techniques for AI-Driven Tumor Subtype Classification: Enhancing Precision in Cancer Diagnostics
Next Article in Special Issue
Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and Management
Previous Article in Journal
PRDM16 Enhances Osteoblastogenic RUNX2 via Canonical WNT10b/β-CATENIN Pathway in Testosterone-Treated Hypogonadal Men
Previous Article in Special Issue
Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomolecules
Volume 15
Issue 1
10.3390/biom15010080
Review Report
biomolecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Caffeic Acid Phenethyl Ester Protects Neurons Against Oxidative Stress and Neurodegeneration During Traumatic Brain Injury

Biomolecules 2025, 15(1), 80; https://doi.org/10.3390/biom15010080
by Nurul Sulimai 1, Jason Brown 1 and David Lominadze 1,2,*
Reviewer 1: Anonymous
Reviewer 2:
Julio Sotelo
Biomolecules 2025, 15(1), 80; https://doi.org/10.3390/biom15010080
Submission received: 10 December 2024 / Revised: 4 January 2025 / Accepted: 6 January 2025 / Published: 8 January 2025
(This article belongs to the Special Issue The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition))

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The authors aimed to evaluate the effect of caffeic acid phenethyl ester (CAPE), an inhibitor of NF-κB, on Fg-induced neurodegeneration in vitro and in mice with mild-to-moderate TBI.

The manuscript has good scientific facts.

The first keyword may be checked from MeSH database.

In the introduction section, please add the sentence- “CAPE has been reported to have anti-inflammatory, antioxidant, neuroprotective, antiviral, antitumoral, antiatherosclerotic, and immunomodulatory properties in a variety of systems”

Does coagulopathy occur in TBI? Possibly due to a combination of hemorrhage and trauma induced coagulopathy, there can be low fibrinogen levels with severe TBI.

Refer to line 346- Instead of using a general term ‘protect blood-brain integrity’ please use the exact word. Does CAPE effectively reduce blood-brain permeability?

Can CAPE may improve BBB integrity by preserving claudin-5 levels? Please discuss this fact.

What is the effect on hippocampal cell loss?

Regarding the neuroprotection offered by CAPE, can the degree of inflammation influence the results?

Author Response

Please see the attached response to reviewer.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

This manuscript is interesting on the relevant issue of neuroprotection, the study is well designed and the text shows important results; I have only a minor suggestion: The title is too long, the line “The role of fibrinogen” could be deleted as the authors did not demonstrate (P8, L308-318) the role of fibrinogen on their results; also, the term “Caffeic acid” would lead to think that caffeine from coffee is proposed (P14,L455-458), I think that the term should be changed from the title (e.g. “A polyphenol…”)

Comments on the Quality of English Language

No comments.

Author Response

Please see the attached response to reviewer.

Author Response File: Author Response.pdf

Back to TopTop