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Volume 14
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Article

Synthesis and Biological Evaluation of Novel Imidazole Derivatives as Antimicrobial Agents

by
Huda A. Al-Ghamdi
1,
Fahad A. Almughem
2,
Manal A. Alshabibi
2,
Abrar A. Bakr
2,
Abdullah A. Alshehri
2,
Alhassan H. Aodah
2,
Nourah A. Al Zahrani
1,
Essam A. Tawfik
2,* and
Laila A. Damiati
3,*
1
Department of Chemistry, College of Science, University of Jeddah, Jeddah 23218, Saudi Arabia
2
Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh 11451, Saudi Arabia
3
Department of Biological Science, College of Science, University of Jeddah, Jeddah 23218, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Biomolecules 2024, 14(9), 1198; https://doi.org/10.3390/biom14091198
Submission received: 23 July 2024 / Revised: 15 September 2024 / Accepted: 20 September 2024 / Published: 23 September 2024
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Abstract

Imidazole derivatives are considered potential chemical compounds that could be therapeutically effective against several harmful pathogenic microbes. The chemical structure of imidazole, with a five-membered heterocycle, three carbon atoms, and two double bonds, tends to show antibacterial activities. In the present study, novel imidazole derivatives were designed and synthesized to be evaluated as antimicrobial agents owing to the low number of attempts to discover new antimicrobial agents and the emerging cases of antimicrobial resistance. Two imidazole compounds were prepared and evaluated as promising candidates regarding in vitro cytotoxicity against human skin fibroblast cells and antimicrobial activity against several bacterial strains. The synthesized imidazole derivatives were chemically identified using nuclear magnetic resonance (NMR) and Fourier-transform infrared spectroscopy (FTIR). The results demonstrated a relatively high cell viability of one of the imidazole derivatives, i.e., HL2, upon 24 and 48 h cell exposure. Both derivatives were able to inhibit the growth of the tested bacterial strains. This study provides valuable insight into the potential application of imidazole derivatives for treating microbial infections; however, further in vitro and in vivo studies are required to confirm their safety and effectiveness.
Keywords: Imidazole derivative; biological activity; antimicrobial activity; cell viability; chemical synthesis Imidazole derivative; biological activity; antimicrobial activity; cell viability; chemical synthesis

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MDPI and ACS Style

Al-Ghamdi, H.A.; Almughem, F.A.; Alshabibi, M.A.; Bakr, A.A.; Alshehri, A.A.; Aodah, A.H.; Al Zahrani, N.A.; Tawfik, E.A.; Damiati, L.A. Synthesis and Biological Evaluation of Novel Imidazole Derivatives as Antimicrobial Agents. Biomolecules 2024, 14, 1198. https://doi.org/10.3390/biom14091198

AMA Style

Al-Ghamdi HA, Almughem FA, Alshabibi MA, Bakr AA, Alshehri AA, Aodah AH, Al Zahrani NA, Tawfik EA, Damiati LA. Synthesis and Biological Evaluation of Novel Imidazole Derivatives as Antimicrobial Agents. Biomolecules. 2024; 14(9):1198. https://doi.org/10.3390/biom14091198

Chicago/Turabian Style

Al-Ghamdi, Huda A., Fahad A. Almughem, Manal A. Alshabibi, Abrar A. Bakr, Abdullah A. Alshehri, Alhassan H. Aodah, Nourah A. Al Zahrani, Essam A. Tawfik, and Laila A. Damiati. 2024. "Synthesis and Biological Evaluation of Novel Imidazole Derivatives as Antimicrobial Agents" Biomolecules 14, no. 9: 1198. https://doi.org/10.3390/biom14091198

APA Style

Al-Ghamdi, H. A., Almughem, F. A., Alshabibi, M. A., Bakr, A. A., Alshehri, A. A., Aodah, A. H., Al Zahrani, N. A., Tawfik, E. A., & Damiati, L. A. (2024). Synthesis and Biological Evaluation of Novel Imidazole Derivatives as Antimicrobial Agents. Biomolecules, 14(9), 1198. https://doi.org/10.3390/biom14091198

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