Next Article in Journal
Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Next Article in Special Issue
Phloridzin Docosahexaenoate, an Omega-3 Fatty Acid Ester of a Flavonoid Precursor, Inhibits Angiogenesis by Suppressing Endothelial Cell Proliferation, Migration, and Differentiation
Previous Article in Journal
Predictive Modeling of Proteins Encoded by a Plant Virus Sheds a New Light on Their Structure and Inherent Multifunctionality
Previous Article in Special Issue
Ethnobotany, Phytochemistry, and Biological Activities of the Genus Cordyline
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomolecules
Volume 14
Issue 1
10.3390/biom14010063
biomolecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases

by
Sri Jayanti
1,2,†,
Libor Vitek
3,†,
Camilla Dalla Verde
1,4,†,
John Paul Llido
1,4,5,
Caecilia Sukowati
1,2,
Claudio Tiribelli
1 and
Silvia Gazzin
1,*
1
Liver brain Unit “Rita Moretti”, Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163,5, Basovizza, 34149 Trieste, Italy
2
Eijkman Research Centre for Molecular Biology, Research Organization for Health, National Research and Innovation Agency, Cibinong 16915, Indonesia
3
Institute of Medical Biochemistry and Laboratory Diagnostics, and 4th Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, 12000 Prague, Czech Republic
4
Department of Life Sciences, University of Trieste, 34139 Trieste, Italy
5
Department of Science and Technology, Philippine Council for Health Research and Development, Bicutan, Taguig City 1631, Philippines
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2024, 14(1), 63; https://doi.org/10.3390/biom14010063
Submission received: 1 December 2023 / Revised: 28 December 2023 / Accepted: 29 December 2023 / Published: 2 January 2024
(This article belongs to the Special Issue The Value of Natural Compounds as Therapeutic Agents)
Browse Figures
Review Reports Versions Notes

Abstract

The crucial physiological process of heme breakdown yields biliverdin (BV) and bilirubin (BR) as byproducts. BV, BR, and the enzymes involved in their production (the “yellow players—YP”) are increasingly documented as endogenous modulators of human health. Mildly elevated serum bilirubin concentration has been correlated with a reduced risk of multiple chronic pro-oxidant and pro-inflammatory diseases, especially in the elderly. BR and BV per se have been demonstrated to protect against neurodegenerative diseases, in which heme oxygenase (HMOX), the main enzyme in the production of pigments, is almost always altered. HMOX upregulation has been interpreted as a tentative defense against the ongoing pathologic mechanisms. With the demonstration that multiple cells possess YP, their propensity to be modulated, and their broad spectrum of activity on multiple signaling pathways, the YP have assumed the role of an adjustable system that can promote health in adults. Based on that, there is an ongoing effort to induce their activity as a therapeutic option, and natural compounds are an attractive alternative to the goal, possibly requiring only minimal changes in the life style. We review the most recent evidence of the potential of natural compounds in targeting the YP in the context of the most common pathologic condition of adult and elderly life.
Keywords: bilirubin; herbal medicine; NRF2; heme-oxygenase; MAFLD; neurodegeneration; nutraceuticals; Alzheimer’s disease; cancer; Parkinson’s disease bilirubin; herbal medicine; NRF2; heme-oxygenase; MAFLD; neurodegeneration; nutraceuticals; Alzheimer’s disease; cancer; Parkinson’s disease
Graphical Abstract

Share and Cite

MDPI and ACS Style

Jayanti, S.; Vitek, L.; Verde, C.D.; Llido, J.P.; Sukowati, C.; Tiribelli, C.; Gazzin, S. Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases. Biomolecules 2024, 14, 63. https://doi.org/10.3390/biom14010063

AMA Style

Jayanti S, Vitek L, Verde CD, Llido JP, Sukowati C, Tiribelli C, Gazzin S. Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases. Biomolecules. 2024; 14(1):63. https://doi.org/10.3390/biom14010063

Chicago/Turabian Style

Jayanti, Sri, Libor Vitek, Camilla Dalla Verde, John Paul Llido, Caecilia Sukowati, Claudio Tiribelli, and Silvia Gazzin. 2024. "Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases" Biomolecules 14, no. 1: 63. https://doi.org/10.3390/biom14010063

APA Style

Jayanti, S., Vitek, L., Verde, C. D., Llido, J. P., Sukowati, C., Tiribelli, C., & Gazzin, S. (2024). Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases. Biomolecules, 14(1), 63. https://doi.org/10.3390/biom14010063

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop