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Volume 13
Issue 7
10.3390/biom13071139
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Review

The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential

by
Fengguang Yang
1,2,3,†,
Jinglin Ma
1,2,3,4,†,
Daxue Zhu
1,2,3,†,
Zhaoheng Wang
1,2,3,
Yanhu Li
1,2,3,
Xuegang He
1,2,3,
Guangzhi Zhang
1,2,3 and
Xuewen Kang
1,2,3,*
1
Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China
2
The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China
3
Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China
4
School of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2023, 13(7), 1139; https://doi.org/10.3390/biom13071139
Submission received: 4 June 2023 / Revised: 11 July 2023 / Accepted: 14 July 2023 / Published: 17 July 2023
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Abstract

S100A6, also known as calcyclin, is a low-molecular-weight Ca2+-binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as melanoma. S100A6 has many molecular functions related to cell proliferation, the cell cycle, cell differentiation, and the cytoskeleton. It is not only involved in tumor invasion, proliferation, and migration, but also the pathogenesis of other non-neoplastic diseases. In this review, we focus on the molecular mechanisms and potential therapeutic targets of S100A6 in tumors, nervous system diseases, leukemia, endometriosis, cardiovascular disease, osteoarthritis, and other related diseases.
Keywords: S100A6; tumor; Alzheimer’s disease; leukemia; endometriosis; myocardial infarction S100A6; tumor; Alzheimer’s disease; leukemia; endometriosis; myocardial infarction

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MDPI and ACS Style

Yang, F.; Ma, J.; Zhu, D.; Wang, Z.; Li, Y.; He, X.; Zhang, G.; Kang, X. The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential. Biomolecules 2023, 13, 1139. https://doi.org/10.3390/biom13071139

AMA Style

Yang F, Ma J, Zhu D, Wang Z, Li Y, He X, Zhang G, Kang X. The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential. Biomolecules. 2023; 13(7):1139. https://doi.org/10.3390/biom13071139

Chicago/Turabian Style

Yang, Fengguang, Jinglin Ma, Daxue Zhu, Zhaoheng Wang, Yanhu Li, Xuegang He, Guangzhi Zhang, and Xuewen Kang. 2023. "The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential" Biomolecules 13, no. 7: 1139. https://doi.org/10.3390/biom13071139

APA Style

Yang, F., Ma, J., Zhu, D., Wang, Z., Li, Y., He, X., Zhang, G., & Kang, X. (2023). The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential. Biomolecules, 13(7), 1139. https://doi.org/10.3390/biom13071139

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