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Review

Mitigating Oxidative Stress in Perinatal Cells: A Critical Step toward an Optimal Therapeutic Use in Regenerative Medicine

by
Valeria Pizzuti
1,†,
Francesca Paris
1,†,
Pasquale Marrazzo
1,*,
Laura Bonsi
1,‡ and
Francesco Alviano
2,‡
1
Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy
2
Department of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
These authors contributed equally to this work.
Biomolecules 2023, 13(6), 971; https://doi.org/10.3390/biom13060971
Submission received: 14 April 2023 / Revised: 26 May 2023 / Accepted: 1 June 2023 / Published: 10 June 2023
(This article belongs to the Special Issue Involvement of Oxidative Stress Signalling Pathways in Cell Death)
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Abstract

Oxidative stress (OS) occurs when the production of reactive oxygen species (ROS) is not balanced by the body’s antioxidant defense system. OS can profoundly affect cellular health and function. ROS can have a profound negative impact on cells that undergo a predestined and time-regulated process of proliferation or differentiation, such as perinatal stem cells. Due to the large-scale employment of these immunotolerant stem cells in regenerative medicine, it is important to reduce OS to prevent them from losing function and increase their application in the regenerative medicine field. This goal can be achieved through a variety of strategies, such as the use of antioxidants and other compounds that can indirectly modulate the antioxidant defense system by enhancing cellular stress response pathways, including autophagy and mitochondrial function, thereby reducing ROS levels. This review aims to summarize information regarding OS mechanisms in perinatal stem cells and possible strategies for reducing their deleterious effects.
Keywords: oxidative stress; reactive oxygen species; cell senescence; antioxidants; mesenchymal stem cells; perinatal cells; regenerative medicine oxidative stress; reactive oxygen species; cell senescence; antioxidants; mesenchymal stem cells; perinatal cells; regenerative medicine

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MDPI and ACS Style

Pizzuti, V.; Paris, F.; Marrazzo, P.; Bonsi, L.; Alviano, F. Mitigating Oxidative Stress in Perinatal Cells: A Critical Step toward an Optimal Therapeutic Use in Regenerative Medicine. Biomolecules 2023, 13, 971. https://doi.org/10.3390/biom13060971

AMA Style

Pizzuti V, Paris F, Marrazzo P, Bonsi L, Alviano F. Mitigating Oxidative Stress in Perinatal Cells: A Critical Step toward an Optimal Therapeutic Use in Regenerative Medicine. Biomolecules. 2023; 13(6):971. https://doi.org/10.3390/biom13060971

Chicago/Turabian Style

Pizzuti, Valeria, Francesca Paris, Pasquale Marrazzo, Laura Bonsi, and Francesco Alviano. 2023. "Mitigating Oxidative Stress in Perinatal Cells: A Critical Step toward an Optimal Therapeutic Use in Regenerative Medicine" Biomolecules 13, no. 6: 971. https://doi.org/10.3390/biom13060971

APA Style

Pizzuti, V., Paris, F., Marrazzo, P., Bonsi, L., & Alviano, F. (2023). Mitigating Oxidative Stress in Perinatal Cells: A Critical Step toward an Optimal Therapeutic Use in Regenerative Medicine. Biomolecules, 13(6), 971. https://doi.org/10.3390/biom13060971

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