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Biomolecules
Volume 12
Issue 6
10.3390/biom12060845
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Review

Genomic Variation-Mediating Fluconazole Resistance in Yeast

by
Wen-Yao Wang
,
Hong-Qing Cai
,
Si-Yuan Qu
,
Wei-Hao Lin
,
Cheng-Cheng Liang
,
Hao Liu
,
Ze-Xiong Xie
* and
Ying-Jin Yuan
Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
*
Author to whom correspondence should be addressed.
Biomolecules 2022, 12(6), 845; https://doi.org/10.3390/biom12060845
Submission received: 28 April 2022 / Revised: 7 June 2022 / Accepted: 9 June 2022 / Published: 17 June 2022
(This article belongs to the Special Issue Theme Issue Honoring Scientist Louis Pasteur on His 200th Birthday)
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Abstract

Fungal infections pose a serious and growing threat to public health. These infections can be treated with antifungal drugs by killing hazardous fungi in the body. However, the resistance can develop over time when fungi are exposed to antifungal drugs by generating genomic variations, including mutation, aneuploidy, and loss of heterozygosity. The variations could reduce the binding affinity of a drug to its target or block the pathway through which drugs exert their activity. Here, we review genomic variation-mediating fluconazole resistance in the yeast Candida, with the hope of highlighting the functional consequences of genomic variations for the antifungal resistance.
Keywords: antifungal resistance; fluconazole; yeast; genomic variations; aneuploidy; loss of heterozygosity antifungal resistance; fluconazole; yeast; genomic variations; aneuploidy; loss of heterozygosity

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MDPI and ACS Style

Wang, W.-Y.; Cai, H.-Q.; Qu, S.-Y.; Lin, W.-H.; Liang, C.-C.; Liu, H.; Xie, Z.-X.; Yuan, Y.-J. Genomic Variation-Mediating Fluconazole Resistance in Yeast. Biomolecules 2022, 12, 845. https://doi.org/10.3390/biom12060845

AMA Style

Wang W-Y, Cai H-Q, Qu S-Y, Lin W-H, Liang C-C, Liu H, Xie Z-X, Yuan Y-J. Genomic Variation-Mediating Fluconazole Resistance in Yeast. Biomolecules. 2022; 12(6):845. https://doi.org/10.3390/biom12060845

Chicago/Turabian Style

Wang, Wen-Yao, Hong-Qing Cai, Si-Yuan Qu, Wei-Hao Lin, Cheng-Cheng Liang, Hao Liu, Ze-Xiong Xie, and Ying-Jin Yuan. 2022. "Genomic Variation-Mediating Fluconazole Resistance in Yeast" Biomolecules 12, no. 6: 845. https://doi.org/10.3390/biom12060845

APA Style

Wang, W.-Y., Cai, H.-Q., Qu, S.-Y., Lin, W.-H., Liang, C.-C., Liu, H., Xie, Z.-X., & Yuan, Y.-J. (2022). Genomic Variation-Mediating Fluconazole Resistance in Yeast. Biomolecules, 12(6), 845. https://doi.org/10.3390/biom12060845

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