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Review

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

1
International Laboratory EPIGEN, Consejo de Ciencia y Tecnología del Estado de Puebla (CONCYTEP), Puebla 72160, Mexico
2
Licenciatura en Médico Cirujano, Universidad de la Salud del Estado de Puebla (USEP), Puebla 72000, Mexico
3
Facultad de Biotecnología, Campus Puebla, Universidad Popular Autónoma del Estado de Puebla (UPAEP), Puebla 72410, Mexico
4
Decanato de Ciencias de la Salud, Campus Puebla, Universidad Popular Autónoma del Estado de Puebla (UPAEP), Puebla 72410, Mexico
5
Laboratoire IMoPA, CNRS, Université de Lorraine, UMR 73635 Nancy, France
6
Lung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
*
Author to whom correspondence should be addressed.
Dr. Guillermo Barreto's primary affiliation is Affiliation 5.
Academic Editor: Ryou-u Takahashi
Biomolecules 2022, 12(4), 513; https://doi.org/10.3390/biom12040513
Received: 25 February 2022 / Revised: 18 March 2022 / Accepted: 21 March 2022 / Published: 28 March 2022
(This article belongs to the Special Issue Non-coding RNAs in Cancer Biology)
Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined as the exposome, which interacts with our unique characteristics such as genetics, physiology, and epigenetics. Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequence. Some studies have confirmed that environmental factors may promote disease in individuals or subsequent progeny through epigenetic alterations. Variations in the epigenetic machinery cause a spectrum of different disorders since these mechanisms are more sensitive to the environment than the genome, due to the inherent reversible nature of the epigenetic landscape. Several epigenetic mechanisms, including modifications in DNA (e.g., methylation), histones, and noncoding RNAs can change genome expression under the exogenous influence. Notably, the role of long noncoding RNAs in epigenetic processes has not been well explored in the context of exposome-induced tumorigenesis. In the present review, our scope is to provide relevant evidence indicating that epigenetic alterations mediate those detrimental effects caused by exposure to environmental toxicants, focusing mainly on a multi-step regulation by diverse noncoding RNAs subtypes. View Full-Text
Keywords: epigenetic reprogramming; environment-related toxicants; tumorigenesis; biomarkers; noncoding RNAs; exposome epigenetic reprogramming; environment-related toxicants; tumorigenesis; biomarkers; noncoding RNAs; exposome
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MDPI and ACS Style

Olmedo-Suárez, M.Á.; Ramírez-Díaz, I.; Pérez-González, A.; Molina-Herrera, A.; Coral-García, M.Á.; Lobato, S.; Sarvari, P.; Barreto, G.; Rubio, K. Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs. Biomolecules 2022, 12, 513. https://doi.org/10.3390/biom12040513

AMA Style

Olmedo-Suárez MÁ, Ramírez-Díaz I, Pérez-González A, Molina-Herrera A, Coral-García MÁ, Lobato S, Sarvari P, Barreto G, Rubio K. Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs. Biomolecules. 2022; 12(4):513. https://doi.org/10.3390/biom12040513

Chicago/Turabian Style

Olmedo-Suárez, Miguel Ángel, Ivonne Ramírez-Díaz, Andrea Pérez-González, Alejandro Molina-Herrera, Miguel Ángel Coral-García, Sagrario Lobato, Pouya Sarvari, Guillermo Barreto, and Karla Rubio. 2022. "Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs" Biomolecules 12, no. 4: 513. https://doi.org/10.3390/biom12040513

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