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Peer-Review Record

Novel Selective and Low-Toxic Inhibitor of LmCPB2.8ΔCTE (CPB) One Important Cysteine Protease for Leishmania Virulence

Biomolecules 2022, 12(12), 1903; https://doi.org/10.3390/biom12121903
by Vitor Partite Moreira 1, Michele Ferreira da Silva Mela 2, Luana Ribeiro dos Anjos 1, Leonardo Figueiredo Saraiva 3, Angela M. Arenas Velásquez 2, Predrag Kalaba 4, Anna Fabisiková 5, Leandro da Costa Clementino 2, Mohammed Aufy 6, Christian Studenik 6, Natalie Gajic 7, Alexander Prado-Roller 7, Alvicler Magalhães 8, Martin Zehl 5,9, Ingrid Delbone Figueiredo 2, Amanda Martins Baviera 2, Eduardo Maffud Cilli 10, Marcia A. S. Graminha 2,*, Gert Lubec 11,* and Eduardo R. Perez Gonzalez 1,*
Reviewer 1:
Reviewer 2:
Biomolecules 2022, 12(12), 1903; https://doi.org/10.3390/biom12121903
Submission received: 23 November 2022 / Revised: 11 December 2022 / Accepted: 12 December 2022 / Published: 19 December 2022
(This article belongs to the Section Chemical Biology)

Round 1

Reviewer 1 Report

Most of the comments are attached to the PDF file. some important comments are:

1. Author have to perform the histology to confirm the toxicity effect?

2. Give the table or figure related to animal treatment in antileishmanial activity?

Comments for author File: Comments.pdf

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

1-In the section of synthesis of guanidines authors need to describe the preparation procedure in brief.

2-  Did authors see any difference in organ toxicity between Guinea pigs as they used both sexes?

3- How did authors decide to use 2mg/kg of LQOF-G6 for treatment of BALB/C mice?

4- Figure 7 needs legend and graphs are not shown well.

5- In line 267, 107 (Inoculated promastigotes), 7 need to be edited to superscript. 

Author Response

please see the attachment

Author Response File: Author Response.pdf

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