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Volume 12
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Systematic Review

The Role of Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review

by
Muhammad Mazhar Fareed
1,
Maryam Qasmi
2,
Shaan Aziz
2,
Elisabeth Völker
3,
Carola Yvette Förster
3 and
Sergey Shityakov
4,*
1
Department of Computer Science, School of Science and Engineering, Università Degli Studi di Verona, Via dell’Artigliere, 8, 37129 Verona, Italy
2
Department of Bioinformatics and Biotechnology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan
3
Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg University Hospital, 97070 Würzburg, Germany
4
Laboratory of Chemoinformatics, Infochemistry Scientific Center, ITMO University, 195251 Saint-Petersburg, Russia
*
Author to whom correspondence should be addressed.
Biomolecules 2022, 12(10), 1452; https://doi.org/10.3390/biom12101452
Submission received: 17 June 2022 / Revised: 30 September 2022 / Accepted: 2 October 2022 / Published: 10 October 2022
(This article belongs to the Special Issue Regulation of the Endothelial Cell Barrier)
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Abstract

Alzheimer’s disease (AD) is considered a chronic and debilitating neurological illness that is increasingly impacting older-age populations. Some proteins, including clusterin (CLU or apolipoprotein J) transporter, can be linked to AD, causing oxidative stress. Therefore, its activity can affect various functions involving complement system inactivation, lipid transport, chaperone activity, neuronal transmission, and cellular survival pathways. This transporter is known to bind to the amyloid beta (Aβ) peptide, which is the major pathogenic factor of AD. On the other hand, this transporter is also active at the blood–brain barrier (BBB), a barrier that prevents harmful substances from entering and exiting the brain. Therefore, in this review, we discuss and emphasize the role of the CLU transporter and CLU-linked molecular mechanisms at the BBB interface in the pathogenesis of AD.
Keywords: clusterin transporter; apolipoprotein J; Wnt signaling; Alzheimer’s disease; AD pathogenesis; blood–brain barrier clusterin transporter; apolipoprotein J; Wnt signaling; Alzheimer’s disease; AD pathogenesis; blood–brain barrier

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MDPI and ACS Style

Fareed, M.M.; Qasmi, M.; Aziz, S.; Völker, E.; Förster, C.Y.; Shityakov, S. The Role of Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review. Biomolecules 2022, 12, 1452. https://doi.org/10.3390/biom12101452

AMA Style

Fareed MM, Qasmi M, Aziz S, Völker E, Förster CY, Shityakov S. The Role of Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review. Biomolecules. 2022; 12(10):1452. https://doi.org/10.3390/biom12101452

Chicago/Turabian Style

Fareed, Muhammad Mazhar, Maryam Qasmi, Shaan Aziz, Elisabeth Völker, Carola Yvette Förster, and Sergey Shityakov. 2022. "The Role of Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review" Biomolecules 12, no. 10: 1452. https://doi.org/10.3390/biom12101452

APA Style

Fareed, M. M., Qasmi, M., Aziz, S., Völker, E., Förster, C. Y., & Shityakov, S. (2022). The Role of Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review. Biomolecules, 12(10), 1452. https://doi.org/10.3390/biom12101452

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