TRP Channels as Molecular Targets to Relieve Cancer Pain
Abstract
:1. Introduction
2. The Structure and Physiological Functions of TRP Channels
3. Activation Mechanisms of TRPV1 and TRPA1
4. Tumor Microenvironment (TM) and Cancer Pain
4.1. Pro-Inflammatory Mediators Associated with Nociceptive Processes
4.2. Acidification of the Tumor Microenvironment
5. The Role of TRP Channels in Cancer Pain
5.1. G protein Coupled Receptor (GPCR)-Mediated Modulation of TRPV1 and TRPA1 Channel Activity
5.2. Modulation of the Activity of the TRPV1 and TRPA1 Channels Mediated through Receptor Tyrosine Kinase A (TrkA)
5.3. Other Mechanisms
6. The Role of TRP Channel Agonists and Antagonists in Cancer Pain
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Channel | Compound | Source | Activity | Reference | |
---|---|---|---|---|---|
Agonist | Antagonist | ||||
TRPV1 | Capsaicin | Capsicum | † | [30] | |
Piperine | Piper nigrum | † | [182] | ||
Resiniferatoxin | Euphorbia resinifera | † | [30] | ||
Evodiamine | Evodia rutaecarpa | † | [183] | ||
Cannabidiol | Cannabis sativa | † | [184] | ||
Polygodial | Polygonum hydropiper | † | [185] | ||
Isovelleral | Lactarius vellereus | † | [186] | ||
Tapsigargina | Thapsia garganica | † | [187] | ||
Yohimbine | Pausinystalia yohimbe | † | [188] | ||
TRPA1 | Allyl isothiocyanate | Wasabi, mustard oil | † | [189] | |
Benzyl isothiocyanate | Yellow mustard | † | [189] | ||
Phenylethyl isothiocyanate | Brussels sprouts | † | [189] | ||
Isopropyl isothiocyanate | Nasturtium seeds | † | [189] | ||
Methyl isothiocyanate | Capparis spinosa | † | [189] | ||
Cinnamaldehyde | Cinnamomum cassia/Cinnamomum zeylanicum | † | [126] | ||
Methyl salicylate | Wintergreen oil | † | [126] | ||
Carvacrol | Origanum genus | † | [190] | ||
Tetrahydrocannabinol | Cannabis genus | † | [189] | ||
Menthol | Mentha | † | [191] | ||
Both of them | Eugenol | Clove oil | TRPV1/TRPA1 | [192] | |
Gingerol | Zingiber officinale | TRPV1/TRPA1 | [126,193] | ||
Camphor | Cinnamomum camphora | TRPV1 | TRPA1 | [194] | |
Allicin | Allium sativum | TRPV1/TRPA1 | [195] |
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Duitama, M.; Moreno, Y.; Santander, S.P.; Casas, Z.; Sutachan, J.J.; Torres, Y.P.; Albarracín, S.L. TRP Channels as Molecular Targets to Relieve Cancer Pain. Biomolecules 2022, 12, 1. https://doi.org/10.3390/biom12010001
Duitama M, Moreno Y, Santander SP, Casas Z, Sutachan JJ, Torres YP, Albarracín SL. TRP Channels as Molecular Targets to Relieve Cancer Pain. Biomolecules. 2022; 12(1):1. https://doi.org/10.3390/biom12010001
Chicago/Turabian StyleDuitama, Milena, Yurany Moreno, Sandra Paola Santander, Zulma Casas, Jhon Jairo Sutachan, Yolima P. Torres, and Sonia L. Albarracín. 2022. "TRP Channels as Molecular Targets to Relieve Cancer Pain" Biomolecules 12, no. 1: 1. https://doi.org/10.3390/biom12010001