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Article

The Prognostic Value of Locoregional Interventions for BRAF V600E Metastatic Colorectal Cancer: A Retrospective Cohort Analysis

by
Liu-Fang Ye
1,2,3,†,
Xiao-Meng Ji
4,†,
Chao Ren
1,2,3,
Zhi-Qiang Wang
1,2,3,
Chun-Ping Lin
5,
Dong-Liang Chen
1,2,3,
Yan-Qing Cai
5,
Ying Jin
1,2,3,
Miao-Zhen Qiu
1,2,3,
Zi-Ming Du
4,
Shao-Yan Xi
6,
Dong-Sheng Zhang
1,2,3,
Feng Wang
1,2,3,
Feng-Hua Wang
1,2,3,
Rui-Hua Xu
1,2,3,
Yu-Hong Li
1,2,3,* and
De-Shen Wang
1,2,3,*
1
Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou 510060, China
2
Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou 510060, China
3
Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
4
Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
5
Department of Oncology, Jieyang Affiliated Hospital, Sun Yat-sen University, Jieyang 522000, China
6
Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this study.
Biomolecules 2021, 11(9), 1268; https://doi.org/10.3390/biom11091268
Submission received: 16 June 2021 / Revised: 19 August 2021 / Accepted: 20 August 2021 / Published: 25 August 2021
(This article belongs to the Special Issue Biomarkers and Therapeutical Targets in Precision Medicine)
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Abstract

The prognostic heterogeneity in patients with BRAF V600E metastatic colorectal cancer (mCRC) remains poorly defined. Real-world data of 93 BRAF V600E mCRC patients from Sun Yat-sen University Cancer Center were evaluated using the prognostic factors affecting overall survival (OS). Treatment of metastases served as an independent prognosticator, where curative locoregional interventions (LRIs) were associated with superior clinical outcomes (adjusted hazard ratio (HR): 0.46, 95% confidence interval (CI): 0.22–0.98; p = 0.044). The LRIs group showed an improved median OS of 49.4 months versus 18.3 months for the palliative treatments (PTs) group. The median OS of patients with colorectal liver metastasis (CRLM) was significantly prolonged after undergoing LRIs (42.4 vs. 23.7 months; HR: 0.11, 95% CI: 0.01–1.22; p = 0.030), and patients in the LRIs plus liver-limited or lung-limited metastasis (LLM) group benefited more than those in the LRIs plus non-LLM group when compared to the PTs group (LLM from LRIs vs. PTs, HR: 0.16, 95% CI: 0.04–0.68; p = 0.006. Non-LLM from LRIs vs. PTs, HR: 0.47, 95% CI: 0.21–1.05; p = 0.074). In conclusion, we confirmed the positive prognostic value of LRIs in BRAF V600E mCRC, particularly in patients with CRLM or LLM.
Keywords: BRAF V600E; metastatic colorectal cancer; prognosis; heterogeneity; locoregional interventions BRAF V600E; metastatic colorectal cancer; prognosis; heterogeneity; locoregional interventions

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MDPI and ACS Style

Ye, L.-F.; Ji, X.-M.; Ren, C.; Wang, Z.-Q.; Lin, C.-P.; Chen, D.-L.; Cai, Y.-Q.; Jin, Y.; Qiu, M.-Z.; Du, Z.-M.; et al. The Prognostic Value of Locoregional Interventions for BRAF V600E Metastatic Colorectal Cancer: A Retrospective Cohort Analysis. Biomolecules 2021, 11, 1268. https://doi.org/10.3390/biom11091268

AMA Style

Ye L-F, Ji X-M, Ren C, Wang Z-Q, Lin C-P, Chen D-L, Cai Y-Q, Jin Y, Qiu M-Z, Du Z-M, et al. The Prognostic Value of Locoregional Interventions for BRAF V600E Metastatic Colorectal Cancer: A Retrospective Cohort Analysis. Biomolecules. 2021; 11(9):1268. https://doi.org/10.3390/biom11091268

Chicago/Turabian Style

Ye, Liu-Fang, Xiao-Meng Ji, Chao Ren, Zhi-Qiang Wang, Chun-Ping Lin, Dong-Liang Chen, Yan-Qing Cai, Ying Jin, Miao-Zhen Qiu, Zi-Ming Du, and et al. 2021. "The Prognostic Value of Locoregional Interventions for BRAF V600E Metastatic Colorectal Cancer: A Retrospective Cohort Analysis" Biomolecules 11, no. 9: 1268. https://doi.org/10.3390/biom11091268

APA Style

Ye, L.-F., Ji, X.-M., Ren, C., Wang, Z.-Q., Lin, C.-P., Chen, D.-L., Cai, Y.-Q., Jin, Y., Qiu, M.-Z., Du, Z.-M., Xi, S.-Y., Zhang, D.-S., Wang, F., Wang, F.-H., Xu, R.-H., Li, Y.-H., & Wang, D.-S. (2021). The Prognostic Value of Locoregional Interventions for BRAF V600E Metastatic Colorectal Cancer: A Retrospective Cohort Analysis. Biomolecules, 11(9), 1268. https://doi.org/10.3390/biom11091268

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