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Transcription-Replication Collisions—A Series of Unfortunate Events

School of Mathematics and Science, Solano Community College, 4000 Suisun Valley Road, Fairfield, CA 94534, USA
Department of Microbiology and Molecular Genetics, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
Authors to whom correspondence should be addressed.
Academic Editor: Francisco J. Blanco
Biomolecules 2021, 11(8), 1249;
Received: 21 July 2021 / Revised: 12 August 2021 / Accepted: 17 August 2021 / Published: 21 August 2021
(This article belongs to the Section Molecular Genetics)
Transcription-replication interactions occur when DNA replication encounters genomic regions undergoing transcription. Both replication and transcription are essential for life and use the same DNA template making conflicts unavoidable. R-loops, DNA supercoiling, DNA secondary structure, and chromatin-binding proteins are all potential obstacles for processive replication or transcription and pose an even more potent threat to genome integrity when these processes co-occur. It is critical to maintaining high fidelity and processivity of transcription and replication while navigating through a complex chromatin environment, highlighting the importance of defining cellular pathways regulating transcription-replication interaction formation, evasion, and resolution. Here we discuss how transcription influences replication fork stability, and the safeguards that have evolved to navigate transcription-replication interactions and maintain genome integrity in mammalian cells. View Full-Text
Keywords: DNA replication; transcription; R-loops; replication stress DNA replication; transcription; R-loops; replication stress
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MDPI and ACS Style

St Germain, C.; Zhao, H.; Barlow, J.H. Transcription-Replication Collisions—A Series of Unfortunate Events. Biomolecules 2021, 11, 1249.

AMA Style

St Germain C, Zhao H, Barlow JH. Transcription-Replication Collisions—A Series of Unfortunate Events. Biomolecules. 2021; 11(8):1249.

Chicago/Turabian Style

St Germain, Commodore, Hongchang Zhao, and Jacqueline H. Barlow. 2021. "Transcription-Replication Collisions—A Series of Unfortunate Events" Biomolecules 11, no. 8: 1249.

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