Next Article in Journal
3D Bioprinting Mesenchymal Stem Cell-Derived Neural Tissues Using a Fibrin-Based Bioink
Previous Article in Journal
The Role of Methionine Residues in the Regulation of Liquid-Liquid Phase Separation
Review

Transcription-Replication Collisions—A Series of Unfortunate Events

1
School of Mathematics and Science, Solano Community College, 4000 Suisun Valley Road, Fairfield, CA 94534, USA
2
Department of Microbiology and Molecular Genetics, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Francisco J. Blanco
Biomolecules 2021, 11(8), 1249; https://doi.org/10.3390/biom11081249
Received: 21 July 2021 / Revised: 12 August 2021 / Accepted: 17 August 2021 / Published: 21 August 2021
(This article belongs to the Section Molecular Genetics)
Transcription-replication interactions occur when DNA replication encounters genomic regions undergoing transcription. Both replication and transcription are essential for life and use the same DNA template making conflicts unavoidable. R-loops, DNA supercoiling, DNA secondary structure, and chromatin-binding proteins are all potential obstacles for processive replication or transcription and pose an even more potent threat to genome integrity when these processes co-occur. It is critical to maintaining high fidelity and processivity of transcription and replication while navigating through a complex chromatin environment, highlighting the importance of defining cellular pathways regulating transcription-replication interaction formation, evasion, and resolution. Here we discuss how transcription influences replication fork stability, and the safeguards that have evolved to navigate transcription-replication interactions and maintain genome integrity in mammalian cells. View Full-Text
Keywords: DNA replication; transcription; R-loops; replication stress DNA replication; transcription; R-loops; replication stress
Show Figures

Figure 1

MDPI and ACS Style

St Germain, C.; Zhao, H.; Barlow, J.H. Transcription-Replication Collisions—A Series of Unfortunate Events. Biomolecules 2021, 11, 1249. https://doi.org/10.3390/biom11081249

AMA Style

St Germain C, Zhao H, Barlow JH. Transcription-Replication Collisions—A Series of Unfortunate Events. Biomolecules. 2021; 11(8):1249. https://doi.org/10.3390/biom11081249

Chicago/Turabian Style

St Germain, Commodore, Hongchang Zhao, and Jacqueline H. Barlow. 2021. "Transcription-Replication Collisions—A Series of Unfortunate Events" Biomolecules 11, no. 8: 1249. https://doi.org/10.3390/biom11081249

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop