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Biomolecules
Volume 11
Issue 6
10.3390/biom11060914
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Review

Paradoxical Roles of Desmosomal Components in Head and Neck Cancer

by
Yin-Qiao Liu
1,
Hai-Ying Zou
1,
Jian-Jun Xie
1,2,* and
Wang-Kai Fang
1,2,*
1
Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, China
2
Precision Medicine Research Center, Shantou University Medical College, Shantou 515041, China
*
Authors to whom correspondence should be addressed.
Biomolecules 2021, 11(6), 914; https://doi.org/10.3390/biom11060914
Submission received: 14 May 2021 / Revised: 14 June 2021 / Accepted: 16 June 2021 / Published: 20 June 2021
(This article belongs to the Special Issue Genetics and Molecular Biology of Head and Neck Cancer)
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Abstract

Desmosomes are intercellular adhesion complexes involved in various aspects of epithelial pathophysiology, including tissue homeostasis, morphogenesis, and disease development. Recent studies have reported that the abnormal expression of various desmosomal components correlates with tumor progression and poor survival. In addition, desmosomes have been shown to act as a signaling platform to regulate the proliferation, invasion, migration, morphogenesis, and apoptosis of cancer cells. The occurrence and progression of head and neck cancer (HNC) is accompanied by abnormal expression of desmosomal components and loss of desmosome structure. However, the role of desmosomal components in the progression of HNC remains controversial. This review aims to provide an overview of recent developments showing the paradoxical roles of desmosomal components in tumor suppression and promotion. It offers valuable insights for HNC diagnosis and therapeutics development.
Keywords: desmosomes; head and neck cancer; desmosomal cadherins; armadillo proteins; plakin proteins desmosomes; head and neck cancer; desmosomal cadherins; armadillo proteins; plakin proteins

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MDPI and ACS Style

Liu, Y.-Q.; Zou, H.-Y.; Xie, J.-J.; Fang, W.-K. Paradoxical Roles of Desmosomal Components in Head and Neck Cancer. Biomolecules 2021, 11, 914. https://doi.org/10.3390/biom11060914

AMA Style

Liu Y-Q, Zou H-Y, Xie J-J, Fang W-K. Paradoxical Roles of Desmosomal Components in Head and Neck Cancer. Biomolecules. 2021; 11(6):914. https://doi.org/10.3390/biom11060914

Chicago/Turabian Style

Liu, Yin-Qiao, Hai-Ying Zou, Jian-Jun Xie, and Wang-Kai Fang. 2021. "Paradoxical Roles of Desmosomal Components in Head and Neck Cancer" Biomolecules 11, no. 6: 914. https://doi.org/10.3390/biom11060914

APA Style

Liu, Y.-Q., Zou, H.-Y., Xie, J.-J., & Fang, W.-K. (2021). Paradoxical Roles of Desmosomal Components in Head and Neck Cancer. Biomolecules, 11(6), 914. https://doi.org/10.3390/biom11060914

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