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Review

Effects of Anthocyanins on Vascular Health

1
Department of Functional Sciences-Pathophysiology, Center for Translational Research and Systems Medicine, “Victor Babes” University of Medicine and Pharmacy, 300173 Timisoara, Romania
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Department of Pharmacology and Biochemistry-Pharmacology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
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Timiş County Emergency Clinical Hospital, 300723 Timisoara, Romania
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Department of Microscopic Morphology-Genetics, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timisoara, Romania
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Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300042 Timisoara, Romania
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2nd Department of Internal Medicine-Endocrinology, “Victor Babeş” University of Medicine and Pharmacy, 300723 Timisoara, Romania
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Department of Cardiology–Cardiology II, “Victor Babeş” University of Medicine and Pharmacy, 300310 Timisoara, Romania
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Institute of Cardiovascular Diseases, 300310 Timisoara, Romania
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Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, Poland
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Faculty of Human Nutrition, Warsaw University of Life Sciences, Nowoursynowska 159 C, 02-776 Warsaw, Poland
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Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria
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Department of Pharmacognosy, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
*
Authors to whom correspondence should be addressed.
Academic Editor: Csaba Szabo
Biomolecules 2021, 11(6), 811; https://doi.org/10.3390/biom11060811
Received: 2 May 2021 / Revised: 26 May 2021 / Accepted: 27 May 2021 / Published: 30 May 2021
Cardiovascular disorders are leading mortality causes worldwide, often with a latent evolution. Vascular health depends on endothelial function, arterial stiffness, and the presence of atherosclerotic plaques. Preventive medicine deserves special attention, focusing on modifiable cardiovascular risk factors, including diet. A diet rich in fruits and vegetables has well-known health benefits, especially due to its polyphenolic components. Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness. The present review aims to give a current overview of the mechanisms involved in the vascular protective effect of anthocyanins from the human diet, considering epidemiological data, in vitro and in vivo preclinical research, clinical observational, retrospective, intervention and randomized studies, dietary and biomarker studies, and discussing preventive benefits of anthocyanins and future research directions. View Full-Text
Keywords: anthocyanins; arterial stiffness; endothelial function; cardiovascular risk; berries; antioxidants anthocyanins; arterial stiffness; endothelial function; cardiovascular risk; berries; antioxidants
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MDPI and ACS Style

Mozos, I.; Flangea, C.; Vlad, D.C.; Gug, C.; Mozos, C.; Stoian, D.; Luca, C.T.; Horbańczuk, J.O.; Horbańczuk, O.K.; Atanasov, A.G. Effects of Anthocyanins on Vascular Health. Biomolecules 2021, 11, 811. https://doi.org/10.3390/biom11060811

AMA Style

Mozos I, Flangea C, Vlad DC, Gug C, Mozos C, Stoian D, Luca CT, Horbańczuk JO, Horbańczuk OK, Atanasov AG. Effects of Anthocyanins on Vascular Health. Biomolecules. 2021; 11(6):811. https://doi.org/10.3390/biom11060811

Chicago/Turabian Style

Mozos, Ioana, Corina Flangea, Daliborca C. Vlad, Cristina Gug, Costin Mozos, Dana Stoian, Constantin T. Luca, Jarosław O. Horbańczuk, Olaf K. Horbańczuk, and Atanas G. Atanasov. 2021. "Effects of Anthocyanins on Vascular Health" Biomolecules 11, no. 6: 811. https://doi.org/10.3390/biom11060811

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