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Neuroprotective Herbs for the Management of Alzheimer’s Disease

Apollo Health, P.O. Box 117040, Burlingame, CA 94011, USA
College of Medicine, University of Central Florida, Orlando, FL 32827, USA
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90024, USA
California College of Ayurveda, 700 Zion Street, Nevada City, CA 95959, USA
Authors to whom correspondence should be addressed.
Academic Editor: Viviana di Giacomo
Biomolecules 2021, 11(4), 543;
Received: 4 March 2021 / Revised: 1 April 2021 / Accepted: 2 April 2021 / Published: 8 April 2021
(This article belongs to the Collection Natural and Synthetic Compounds in Neurodegenerative Disorders)
Background—Alzheimer’s disease (AD) is a multifactorial, progressive, neurodegenerative disease that is characterized by memory loss, personality changes, and a decline in cognitive function. While the exact cause of AD is still unclear, recent studies point to lifestyle, diet, environmental, and genetic factors as contributors to disease progression. The pharmaceutical approaches developed to date do not alter disease progression. More than two hundred promising drug candidates have failed clinical trials in the past decade, suggesting that the disease and its causes may be highly complex. Medicinal plants and herbal remedies are now gaining more interest as complementary and alternative interventions and are a valuable source for developing drug candidates for AD. Indeed, several scientific studies have described the use of various medicinal plants and their principal phytochemicals for the treatment of AD. This article reviews a subset of herbs for their anti-inflammatory, antioxidant, and cognitive-enhancing effects. Methods—This article systematically reviews recent studies that have investigated the role of neuroprotective herbs and their bioactive compounds for dementia associated with Alzheimer’s disease and pre-Alzheimer’s disease. PubMed Central, Scopus, and Google Scholar databases of articles were collected, and abstracts were reviewed for relevance to the subject matter. Conclusions—Medicinal plants have great potential as part of an overall program in the prevention and treatment of cognitive decline associated with AD. It is hoped that these medicinal plants can be used in drug discovery programs for identifying safe and efficacious small molecules for AD. View Full-Text
Keywords: herbs; Alzheimer’s disease; neurodegeneration; ashwagandha; brahmi; cat’s claw; ginkgo biloba; gotu kola; lion’s mane; saffron; shankhpushpi; turmeric; triphala herbs; Alzheimer’s disease; neurodegeneration; ashwagandha; brahmi; cat’s claw; ginkgo biloba; gotu kola; lion’s mane; saffron; shankhpushpi; turmeric; triphala
MDPI and ACS Style

Gregory, J.; Vengalasetti, Y.V.; Bredesen, D.E.; Rao, R.V. Neuroprotective Herbs for the Management of Alzheimer’s Disease. Biomolecules 2021, 11, 543.

AMA Style

Gregory J, Vengalasetti YV, Bredesen DE, Rao RV. Neuroprotective Herbs for the Management of Alzheimer’s Disease. Biomolecules. 2021; 11(4):543.

Chicago/Turabian Style

Gregory, Julie, Yasaswi V. Vengalasetti, Dale E. Bredesen, and Rammohan V. Rao. 2021. "Neuroprotective Herbs for the Management of Alzheimer’s Disease" Biomolecules 11, no. 4: 543.

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