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Article

Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans

1
Department of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, Sweden
2
Centre for Statistics, The Swedish University of Agricultural Sciences, SE-752 36 Uppsala, Sweden
3
Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, 14152 Huddinge, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Natalija Filipović
Biomolecules 2021, 11(3), 396; https://doi.org/10.3390/biom11030396
Received: 29 December 2020 / Revised: 1 March 2021 / Accepted: 2 March 2021 / Published: 8 March 2021
(This article belongs to the Special Issue Biomolecules in Development and Diseases of Urogenital system)
The aim of the present study was to study the associations between urine albumin excretion, and a large number of urinary chemokines, cytokines, and growth factors in a normal population. We selected 90 urine samples from individuals without CVD, diabetes, stroke or kidney disease belonging to the Prospective Investigation of the Vasculature in Uppsala Seniors Study (41 males and 49 females, all aged 75 years). Urinary cytokine levels were analyzed with two multiplex assays (proximity extension assays) and the cytokine levels were correlated with urine albumin. After adjustment for sex, body mass index (BMI), estimated glomerular filtration rate (eGFR), smoking and multiplicity testing, 11 biomarkers remained significantly associated with urine albumin: thrombospondin 2, interleukin 6, interleukin 8, hepatocyte growth factor, matrix metalloproteinase-12 (MMP-12), C-X-C motif chemokine 9, tumor necrosis factor receptor superfamily member 11B, osteoprotegerin, growth-regulated alpha protein, C-X-C motif chemokine 6, oncostatin-M (OSM) and fatty acid-binding protein, intestinal, despite large differences in molecular weights. In this study, we found associations between urinary albumin and both small and large urine proteins. Additional studies are warranted to identify cytokine patterns and potential progression markers in various renal diseases. View Full-Text
Keywords: glomerular injury; urine; thrombospondin 2; interleukin 6; interleukin 8; hepatocyte growth factor glomerular injury; urine; thrombospondin 2; interleukin 6; interleukin 8; hepatocyte growth factor
MDPI and ACS Style

Fellström, B.; Helmersson-Karlqvist, J.; Lind, L.; Soveri, I.; Thulin, M.; Ärnlöv, J.; Kultima, K.; Larsson, A. Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans. Biomolecules 2021, 11, 396. https://doi.org/10.3390/biom11030396

AMA Style

Fellström B, Helmersson-Karlqvist J, Lind L, Soveri I, Thulin M, Ärnlöv J, Kultima K, Larsson A. Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans. Biomolecules. 2021; 11(3):396. https://doi.org/10.3390/biom11030396

Chicago/Turabian Style

Fellström, Bengt, Johanna Helmersson-Karlqvist, Lars Lind, Inga Soveri, Måns Thulin, Johan Ärnlöv, Kim Kultima, and Anders Larsson. 2021. "Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans" Biomolecules 11, no. 3: 396. https://doi.org/10.3390/biom11030396

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