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Article

Impacts of Maternal Diet and Alcohol Consumption during Pregnancy on Maternal and Infant Gut Microbiota

1
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China
2
Wuhan University School of Health Sciences, Wuhan University, 169 Donghu Road, Wuhan 430071, China
3
Nell Hodgson Woodruff School of Nursing, Emory University, 1520 Clifton Road, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Natalia Osna
Biomolecules 2021, 11(3), 369; https://doi.org/10.3390/biom11030369
Received: 4 January 2021 / Revised: 22 February 2021 / Accepted: 24 February 2021 / Published: 1 March 2021
(This article belongs to the Special Issue Alcohol and Molecules)
(1) Background: Maternal diet and alcohol consumption can influence both maternal and infant’s gut microbiota. These relationships are still not examined in the Chinese population. The purpose of this study was to explore the effect of alcohol consumption and maternal diet during pregnancy on maternal and infant’s gut microbiota. (2) Methods: Twenty-nine mother-child dyads were enrolled in central China. Fecal samples of mothers during late pregnancy and of newborns within 48 h were collected. The V3–V4 regions of 16S rRNA sequences were analyzed. A self-administrated questionnaire about simple diet frequency in the past week was completed by mothers before childbirth. The demographic information was finished by mothers at 24 h after childbirth. (3) Results: Among these 29 mothers, 10 mothers reported alcohol consumption during pregnancy. The PCoA (β-diversity) showed significant difference in maternal gut microbiota between the alcohol consumption group vs. the non-alcohol consumption group (abund-Jaccard, r = 0.2, p = 0.006). The same phenomenon was observed in newborns (unweighted-UniFrac full tree, r = 0.174, p = 0.031). Maternal alcohol consumption frequency showed positive associations with maternal Phascolarctobacterium (p = 0.032) and Blautia (p = 0.019); maternal Faecalibacterium (p = 0.013) was negatively correlated with frequency of alcohol consumption. As for newborns, a positive relationship showed between Megamonas (p = 0.035) and newborns with maternal alcohol consumption. The diet was not associated with both maternal and infant’s gut microbiota. (4) Conclusions: Maternal alcohol consumption during pregnancy influenced the gut microbiota on both mothers and the newborns. Future research is needed to explore these relationships in a lager birth cohort. Understanding the long-term effect of alcohol consumption on maternal and newborns’ gut microbiota is needed. View Full-Text
Keywords: gut microbiota; infant; alcohol consumption; maternal diet; pregnancy gut microbiota; infant; alcohol consumption; maternal diet; pregnancy
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MDPI and ACS Style

Wang, Y.; Xie, T.; Wu, Y.; Liu, Y.; Zou, Z.; Bai, J. Impacts of Maternal Diet and Alcohol Consumption during Pregnancy on Maternal and Infant Gut Microbiota. Biomolecules 2021, 11, 369. https://doi.org/10.3390/biom11030369

AMA Style

Wang Y, Xie T, Wu Y, Liu Y, Zou Z, Bai J. Impacts of Maternal Diet and Alcohol Consumption during Pregnancy on Maternal and Infant Gut Microbiota. Biomolecules. 2021; 11(3):369. https://doi.org/10.3390/biom11030369

Chicago/Turabian Style

Wang, Ying, Tianqu Xie, Yinyin Wu, Yanqun Liu, Zhijie Zou, and Jinbing Bai. 2021. "Impacts of Maternal Diet and Alcohol Consumption during Pregnancy on Maternal and Infant Gut Microbiota" Biomolecules 11, no. 3: 369. https://doi.org/10.3390/biom11030369

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