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Open AccessArticle

Enhanced Production of Photosynthetic Pigments and Various Metabolites and Lipids in the Cyanobacteria Synechocystis sp. PCC 7338 Culture in the Presence of Exogenous Glucose

1
College of Pharmacy, Chung-Ang University, Seoul 06974, Korea
2
Department of Biological Engineering, Inha University, Incheon 22212, Korea
3
College of Pharmacy, Gachon University, Incheon 13120, Korea
4
Department of Chemical Engineering and Applied Chemistry, Chungnam National University, Daejeon 34134, Korea
5
Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
*
Author to whom correspondence should be addressed.
These authors equally contribute to this work.
Academic Editor: Philippe Michaud
Biomolecules 2021, 11(2), 214; https://doi.org/10.3390/biom11020214
Received: 17 December 2020 / Revised: 29 January 2021 / Accepted: 29 January 2021 / Published: 3 February 2021
Synechocystis strains are cyanobacteria that can produce useful biomaterials for biofuel and pharmaceutical resources. In this study, the effects of exogenous glucose (5-mM) on cell growth, photosynthetic pigments, metabolites, and lipids in Synechocystis sp. PCC 7338 (referred to as Synechocystis 7338) were investigated. Exogenous glucose increased cell growth on days 9 and 18. The highest production (mg/L) of chlorophyll a (34.66), phycocyanin (84.94), allophycocyanin (34.28), and phycoerythrin (6.90) was observed on day 18 in Synechocystis 7338 culture under 5-mM glucose. Alterations in metabolic and lipidomic profiles under 5-mM glucose were investigated using gas chromatography-mass spectrometry (MS) and nanoelectrospray ionization-MS. The highest production (relative intensity/L) of aspartic acid, glutamic acid, glycerol-3-phosphate, linolenic acid, monogalactosyldiacylglycerol (MGDG) 16:0/18:1, MGDG 16:0/20:2, MGDG 18:1/18:2, neophytadiene, oleic acid, phosphatidylglycerol (PG) 16:0/16:0, and PG 16:0/17:2 was achieved on day 9. The highest production of pyroglutamic acid and sucrose was observed on day 18. We suggest that the addition of exogenous glucose to Synechocystis 7338 culture could be an efficient strategy for improving growth of cells and production of photosynthetic pigments, metabolites, and intact lipid species for industrial applications. View Full-Text
Keywords: Synechocystis 7338; exogenous glucose; photosynthetic pigments; metabolic profiling; lipidomic profiling; GC-MS; nanoESI-MS Synechocystis 7338; exogenous glucose; photosynthetic pigments; metabolic profiling; lipidomic profiling; GC-MS; nanoESI-MS
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MDPI and ACS Style

Noh, Y.; Lee, H.; Kim, M.; Hong, S.-J.; Lee, H.; Kim, D.-M.; Cho, B.-K.; Lee, C.-G.; Choi, H.-K. Enhanced Production of Photosynthetic Pigments and Various Metabolites and Lipids in the Cyanobacteria Synechocystis sp. PCC 7338 Culture in the Presence of Exogenous Glucose. Biomolecules 2021, 11, 214. https://doi.org/10.3390/biom11020214

AMA Style

Noh Y, Lee H, Kim M, Hong S-J, Lee H, Kim D-M, Cho B-K, Lee C-G, Choi H-K. Enhanced Production of Photosynthetic Pigments and Various Metabolites and Lipids in the Cyanobacteria Synechocystis sp. PCC 7338 Culture in the Presence of Exogenous Glucose. Biomolecules. 2021; 11(2):214. https://doi.org/10.3390/biom11020214

Chicago/Turabian Style

Noh, YuJin; Lee, Hwanhui; Kim, Myeongsun; Hong, Seong-Joo; Lee, Hookeun; Kim, Dong-Myung; Cho, Byung-Kwan; Lee, Choul-Gyun; Choi, Hyung-Kyoon. 2021. "Enhanced Production of Photosynthetic Pigments and Various Metabolites and Lipids in the Cyanobacteria Synechocystis sp. PCC 7338 Culture in the Presence of Exogenous Glucose" Biomolecules 11, no. 2: 214. https://doi.org/10.3390/biom11020214

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