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Article

Anthelmintic Activity and Cytotoxic Effects of Compounds Isolated from the Fruits of Ozoroa insignis Del. (Anacardiaceae)

1
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, D-06120 Halle (Saale), Germany
2
Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé P.O. Box 812, Cameroon
3
Department of Biological Sciences, Faculty of Science, University of Botswana, Gaborone P.O. Box 0022, Botswana
4
Institute of Pharmacy, Faculty of Natural Sciences, Martin-Luther-University Halle-Wittenberg, D-06120 Halle (Saale), Germany
5
Swiss Tropical and Public Health Institute, CH-4051 Basel, Switzerland
6
University of Basel, CH-4051 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editors: Eleonora Pagnotta and Luisa Ugolini
Biomolecules 2021, 11(12), 1893; https://doi.org/10.3390/biom11121893
Received: 12 November 2021 / Revised: 7 December 2021 / Accepted: 15 December 2021 / Published: 17 December 2021
(This article belongs to the Special Issue Bioactive Natural Compounds against Animal and Human Pathogens)
Ozoroa insignis Del. is an ethnobotanical plant widely used in traditional medicine for various ailments, including schistosomiasis, tapeworm, and hookworm infections. From the so far not investigated fruits of Ozoroa insignis, the anthelmintic principles could be isolated through bioassay-guided isolation using Caenorhabditis elegans and identified by NMR spectroscopic analysis and mass spectrometric studies. Isolated 6-[8(Z)-pentadecenyl] anacardic (1), 6-[10(Z)-heptadecenyl] anacardic acid (2), and 3-[7(Z)-pentadecenyl] phenol (3) were evaluated against the 5 parasitic organisms Schistosoma mansoni (adult and newly transformed schistosomula), Strongyloides ratti, Heligmosomoides polygyrus, Necator americanus, and Ancylostoma ceylanicum, which mainly infect humans and other mammals. Compounds 13 showed good activity against Schistosoma mansoni, with compound 1 showing the best activity against newly transformed schistosomula with 50% activity at 1µM. The isolated compounds were also evaluated for their cytotoxic properties against PC-3 (human prostate adenocarcinoma) and HT-29 (human colorectal adenocarcinoma) cell lines, whereby compounds 2 and 3 showed antiproliferative activity in both cancer cell lines, while compound 1 exhibited antiproliferative activity only on PC-3 cells. With an IC50 value of 43.2 µM, compound 3 was found to be the most active of the 3 investigated compounds. View Full-Text
Keywords: Ozoroa insignis Del.; fruits; anthelmintic properties; cytotoxicity; Caenorhabditis elegans; parasitic worms Ozoroa insignis Del.; fruits; anthelmintic properties; cytotoxicity; Caenorhabditis elegans; parasitic worms
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MDPI and ACS Style

Dube, M.; Saoud, M.; Rennert, R.; Fotso, G.W.; Andrae-Marobela, K.; Imming, P.; Häberli, C.; Keiser, J.; Arnold, N. Anthelmintic Activity and Cytotoxic Effects of Compounds Isolated from the Fruits of Ozoroa insignis Del. (Anacardiaceae). Biomolecules 2021, 11, 1893. https://doi.org/10.3390/biom11121893

AMA Style

Dube M, Saoud M, Rennert R, Fotso GW, Andrae-Marobela K, Imming P, Häberli C, Keiser J, Arnold N. Anthelmintic Activity and Cytotoxic Effects of Compounds Isolated from the Fruits of Ozoroa insignis Del. (Anacardiaceae). Biomolecules. 2021; 11(12):1893. https://doi.org/10.3390/biom11121893

Chicago/Turabian Style

Dube, Mthandazo, Mohamad Saoud, Robert Rennert, Ghislain Wabo Fotso, Kerstin Andrae-Marobela, Peter Imming, Cécile Häberli, Jennifer Keiser, and Norbert Arnold. 2021. "Anthelmintic Activity and Cytotoxic Effects of Compounds Isolated from the Fruits of Ozoroa insignis Del. (Anacardiaceae)" Biomolecules 11, no. 12: 1893. https://doi.org/10.3390/biom11121893

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