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Review

Polyphenol and Tannin Nutraceuticals and Their Metabolites: How the Human Gut Microbiota Influences Their Properties

1
Microbiomics Unit, Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
2
Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Eleonora Pagnotta and Luisa Ugolini
Biomolecules 2022, 12(7), 875; https://doi.org/10.3390/biom12070875
Received: 31 May 2022 / Revised: 17 June 2022 / Accepted: 21 June 2022 / Published: 23 June 2022
(This article belongs to the Special Issue Bioactive Natural Compounds against Animal and Human Pathogens)
Nutraceuticals have been receiving increasing attention in the last few years due to their potential role as adjuvants against non-communicable chronic diseases (cardiovascular disease, diabetes, cancer, etc.). However, a limited number of studies have been performed to evaluate the bioavailability of such compounds, and it is generally reported that a substantial elevation of their plasma concentration can only be achieved when they are consumed at pharmacological levels. Even so, positive effects have been reported associated with an average dietary consumption of several nutraceutical classes, meaning that the primary compound might not be solely responsible for all the biological effects. The in vivo activities of such biomolecules might be carried out by metabolites derived from gut microbiota fermentative transformation. This review discusses the structure and properties of phenolic nutraceuticals (i.e., polyphenols and tannins) and the putative role of the human gut microbiota in influencing the beneficial effects of such compounds. View Full-Text
Keywords: polyphenol; nutraceutical; microbiota; metabolites; tannin polyphenol; nutraceutical; microbiota; metabolites; tannin
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MDPI and ACS Style

Fabbrini, M.; D’Amico, F.; Barone, M.; Conti, G.; Mengoli, M.; Brigidi, P.; Turroni, S. Polyphenol and Tannin Nutraceuticals and Their Metabolites: How the Human Gut Microbiota Influences Their Properties. Biomolecules 2022, 12, 875. https://doi.org/10.3390/biom12070875

AMA Style

Fabbrini M, D’Amico F, Barone M, Conti G, Mengoli M, Brigidi P, Turroni S. Polyphenol and Tannin Nutraceuticals and Their Metabolites: How the Human Gut Microbiota Influences Their Properties. Biomolecules. 2022; 12(7):875. https://doi.org/10.3390/biom12070875

Chicago/Turabian Style

Fabbrini, Marco, Federica D’Amico, Monica Barone, Gabriele Conti, Mariachiara Mengoli, Patrizia Brigidi, and Silvia Turroni. 2022. "Polyphenol and Tannin Nutraceuticals and Their Metabolites: How the Human Gut Microbiota Influences Their Properties" Biomolecules 12, no. 7: 875. https://doi.org/10.3390/biom12070875

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