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Mulinane- and Azorellane-Type Diterpenoids: A Systematic Review of Their Biosynthesis, Chemistry, and Pharmacology

Unidad de Investigación Médica Yucatán, Unidad Médica de Alta Especialidad Hospital de Especialidades 1 Mérida, Yucatán, Instituto Mexicano del Seguro Social, Mérida 97150, Yucatán, Mexico
Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Antofagasta 02800, Chile
Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, A.C., Mérida 97205, Yucatán, Mexico
Author to whom correspondence should be addressed.
Equally contributing authors.
Biomolecules 2020, 10(9), 1333;
Received: 31 August 2020 / Revised: 14 September 2020 / Accepted: 15 September 2020 / Published: 17 September 2020
(This article belongs to the Section Chemical Biology)
Mulinane- and azorellane-type diterpenoids have unique tricyclic fused five-, six-, and seven-membered systems and a wide range of biological properties, including antimicrobial, antiprotozoal, spermicidal, gastroprotective, and anti-inflammatory, among others. These secondary metabolites are exclusive constituents of medicinal plants belonging to the Azorella, Laretia, and Mulinum genera. In the last 30 years, more than 95 mulinanes and azorellanes have been reported, 49 of them being natural products, 4 synthetics, and the rest semisynthetic and biotransformed derivatives. This systematic review highlights the biosynthetic origin, the chemistry, and the pharmacological activities of this remarkably interesting group of diterpenoids. View Full-Text
Keywords: mulinane; azorellane; diterpenoids; antimycobacterial; antiulcer mulinane; azorellane; diterpenoids; antimycobacterial; antiulcer
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MDPI and ACS Style

Dzul-Beh, A.J.; Uc-Cachón, A.H.; Bórquez, J.; Loyola, L.A.; Peña-Rodríguez, L.M.; Molina-Salinas, G.M. Mulinane- and Azorellane-Type Diterpenoids: A Systematic Review of Their Biosynthesis, Chemistry, and Pharmacology. Biomolecules 2020, 10, 1333.

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