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Review

On the Detection and Functional Significance of the Protein–Protein Interactions of Mitochondrial Transport Proteins

by 1,2,* and 1,2,*
1
Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria
2
Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(8), 1107; https://doi.org/10.3390/biom10081107
Received: 29 May 2020 / Revised: 21 July 2020 / Accepted: 23 July 2020 / Published: 25 July 2020
(This article belongs to the Special Issue Mitochondrial Transport Proteins)
Protein–protein assemblies are highly prevalent in all living cells. Considerable evidence has recently accumulated suggesting that particularly transient association/dissociation of proteins represent an important means of regulation of metabolism. This is true not only in the cytosol and organelle matrices, but also at membrane surfaces where, for example, receptor complexes, as well as those of key metabolic pathways, are common. Transporters also frequently come up in lists of interacting proteins, for example, binding proteins that catalyze the production of their substrates or that act as relays within signal transduction cascades. In this review, we provide an update of technologies that are used in the study of such interactions with mitochondrial transport proteins, highlighting the difficulties that arise in their use for membrane proteins and discussing our current understanding of the biological function of such interactions. View Full-Text
Keywords: protein–protein interaction; inner mitochondrial membrane; mitochondrial carrier family protein–protein interaction; inner mitochondrial membrane; mitochondrial carrier family
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MDPI and ACS Style

Zhang, Y.; Fernie, A.R. On the Detection and Functional Significance of the Protein–Protein Interactions of Mitochondrial Transport Proteins. Biomolecules 2020, 10, 1107. https://doi.org/10.3390/biom10081107

AMA Style

Zhang Y, Fernie AR. On the Detection and Functional Significance of the Protein–Protein Interactions of Mitochondrial Transport Proteins. Biomolecules. 2020; 10(8):1107. https://doi.org/10.3390/biom10081107

Chicago/Turabian Style

Zhang, Youjun; Fernie, Alisdair R. 2020. "On the Detection and Functional Significance of the Protein–Protein Interactions of Mitochondrial Transport Proteins" Biomolecules 10, no. 8: 1107. https://doi.org/10.3390/biom10081107

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