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Biomolecules
Volume 10
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10.3390/biom10040502
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Article

Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway

by
Bharath Kumar Velmurugan
1,
Jen-Tsun Lin
2,3,
B. Mahalakshmi
4,
Yi-Ching Chuang
5,
Chia-Chieh Lin
5,
Yu-Sheng Lo
5,
Ming-Ju Hsieh
5,6,7,8,* and
Mu-Kuan Chen
9,*
1
Toxicology and Biomedicine Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
2
Division of Hematology and Oncology, Department of Medicine, Changhua Christian Hospital, Changhua 500, Taiwan
3
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
4
Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam
5
Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
6
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
7
Department of Holistic Wellness, MingDao University, Changhua 52345, Taiwan
8
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
9
Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua 500, Taiwan
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(4), 502; https://doi.org/10.3390/biom10040502
Submission received: 28 February 2020 / Revised: 23 March 2020 / Accepted: 23 March 2020 / Published: 26 March 2020
(This article belongs to the Special Issue Phytochemical Omics in Medicinal Plants)
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Abstract

Oral squamous cell carcinoma is the sixth most common type of cancer globally, which is associated with high rates of cancer-related deaths. Metastasis to distant organs is the main reason behind worst prognostic outcome of oral cancer. In the present study, we aimed at evaluating the effects of a natural plant flavonoid, luteolin-7-O-glucoside, on oral cancer cell migration and invasion. The study findings showed that in addition to preventing cell proliferation, luteolin-7-O-glucoside caused a significant reduction in oral cancer cell migration and invasion. Mechanistically, luteolin-7-O-glucoside caused a reduction in cancer metastasis by reducing p38 phosphorylation and downregulating matrix metalloproteinase (MMP)-2 expression. Using a p38 inhibitor, SB203580, we proved that luteolin-7-O-glucoside exerts anti-migratory effects by suppressing p38-mediated increased expression of MMP-2. This is the first study to demonstrate the luteolin-7-O-glucoside inhibits cell migration and invasion by regulating MMP-2 expression and extracellular signal-regulated kinase pathway in human oral cancer cell. The study identifies luteolin-7-O-glucoside as a potential anti-cancer candidate that can be utilized clinically for improving oral cancer prognosis.
Keywords: luteolin-7-O-glucoside; oral cancer; migration; invasion; MMP-2 luteolin-7-O-glucoside; oral cancer; migration; invasion; MMP-2
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MDPI and ACS Style

Velmurugan, B.K.; Lin, J.-T.; Mahalakshmi, B.; Chuang, Y.-C.; Lin, C.-C.; Lo, Y.-S.; Hsieh, M.-J.; Chen, M.-K. Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway. Biomolecules 2020, 10, 502. https://doi.org/10.3390/biom10040502

AMA Style

Velmurugan BK, Lin J-T, Mahalakshmi B, Chuang Y-C, Lin C-C, Lo Y-S, Hsieh M-J, Chen M-K. Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway. Biomolecules. 2020; 10(4):502. https://doi.org/10.3390/biom10040502

Chicago/Turabian Style

Velmurugan, Bharath Kumar, Jen-Tsun Lin, B. Mahalakshmi, Yi-Ching Chuang, Chia-Chieh Lin, Yu-Sheng Lo, Ming-Ju Hsieh, and Mu-Kuan Chen. 2020. "Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway" Biomolecules 10, no. 4: 502. https://doi.org/10.3390/biom10040502

APA Style

Velmurugan, B. K., Lin, J.-T., Mahalakshmi, B., Chuang, Y.-C., Lin, C.-C., Lo, Y.-S., Hsieh, M.-J., & Chen, M.-K. (2020). Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway. Biomolecules, 10(4), 502. https://doi.org/10.3390/biom10040502

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