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Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

Department of Physiology, São Paulo State University (Unesp), Institute of Biosciences, Botucatu, São Paulo 18618-970, Brazil
Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba 58051-900, Brazil
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(2), 265;
Received: 27 December 2019 / Revised: 3 February 2020 / Accepted: 5 February 2020 / Published: 10 February 2020
(This article belongs to the Special Issue Pharmacology of Medicinal Plants)
Peptic ulcer disease (PUD) is a multifactorial and complex disease caused by an imbalance of protective and aggressive factors (endogenous and exogenous). Despite advances in recent years, it is still responsible for substantial mortality and triggering clinical problems. Over the last decades, the understanding of PUD has changed a lot with the discovery of Helicobacter pylori infection. However, this disease continues to be a challenge due to side-effects, incidence of relapse from use of various anti-ulcer medicines, and the rapid appearance of antimicrobial resistance with current H. pylori therapies. Consequently, there is the need to identify more effective and safe anti-ulcer agents. The search for new therapies with natural products is a viable alternative and has been encouraged. The literature reports the importance of monoterpenes based on the extensive pharmacological action of this class, including wound healing and anti-ulcerogenic agents. In the present study, 20 monoterpenes with anti-ulcerogenic properties were evaluated by assessing recent in vitro and in vivo studies. Here, we review the anti-ulcer effects of monoterpenes against ulcerogenic factors such as ethanol, nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori, highlighting challenges in the field.
Keywords: Peptic ulcer disease; monoterpenes; anti-ulcer agent; Helicobacter pylori Peptic ulcer disease; monoterpenes; anti-ulcer agent; Helicobacter pylori
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Périco, L.L.; Emílio-Silva, M.T.; Ohara, R.; Rodrigues, V.P.; Bueno, G.; Barbosa-Filho, J.M.; Rocha, L.R.M.; Batista, L.M.; Hiruma-Lima, C.A. Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases. Biomolecules 2020, 10, 265.

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