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Open AccessArticle

Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males

1
Department of Psychiatry, Psychiatric Hospital for Children and Youth Zagreb, Kukuljeviceva 11, 10000 Zagreb, Croatia
2
Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka cesta 54, 10000 Zagreb, Croatia
3
Department for Child and Adolescent Psychiatry, Clinical Hospital Center Osijek, J. Huttlera 4, 31000 Osijek, Croatia
4
Family Medicine, Osijek Health Center, Park Kralja Petra Krešimira IV. 6, 31000 Osijek, Croatia
5
Juvenile Correctional Facility Ivanec, Pahinsko 6, 42240 Ivanec, Croatia
6
Department of Pharmacology & Toxicology, College of Pharmacy, Salt Lake City, 30 South 2000 East, UT 84112, USA
*
Author to whom correspondence should be addressed.
Authors equally contributed to this study.
Biomolecules 2020, 10(11), 1555; https://doi.org/10.3390/biom10111555
Received: 28 September 2020 / Revised: 6 November 2020 / Accepted: 13 November 2020 / Published: 15 November 2020
Juvenile delinquency is related to several biological factors, yet very few vulnerability biomarkers have been identified. Previous data suggest that the enzyme monoamine oxidase B (MAO-B) influences several personality traits linked to the propensity to engage in delinquent behavior. Building on this evidence, we assessed whether conduct disorder (CD), juvenile delinquency adjudications, or detention in a correctional facility were associated with either platelet MAO-B activity or the MAOB rs1799836 polymorphism. The study enrolled 289 medication-free male youths, including 182 individuals detained in a correctional facility (with or without a diagnosis of CD). Of the remaining 107 participants, 26 subjects had a diagnosis of CD, and 81 were mentally healthy controls. Platelet MAO-B activity was determined by spectrophotofluorometry, while MAOB rs1799836 was genotyped using qPCR. Platelet MAO-B activity, corrected for age and smoking, was significantly higher in juvenile detainees (p < 0.001), irrespective of CD diagnosis. MAOB rs1799836 was not associated with platelet MAO-B activity or with detention in a correctional facility, CD diagnosis, or delinquent behavior. These data suggest that detention in a juvenile correctional facility increases platelet MAO-B activity in male adolescents. Future studies are needed to determine the mechanisms and functional significance of MAO-B peripheral elevation in juvenile male detainees. View Full-Text
Keywords: juvenile correctional facility; delinquent behavior; platelet MAO-B activity; MAOB rs1799836 polymorphism; conduct disorder juvenile correctional facility; delinquent behavior; platelet MAO-B activity; MAOB rs1799836 polymorphism; conduct disorder
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MDPI and ACS Style

Podobnik, J.; Nikolac Perkovic, M.; Nedic Erjavec, G.; Dodig Curkovic, K.; Curkovic, M.; Kovac, V.; Svob Strac, D.; Cusek, M.; Bortolato, M.; Pivac, N. Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males. Biomolecules 2020, 10, 1555. https://doi.org/10.3390/biom10111555

AMA Style

Podobnik J, Nikolac Perkovic M, Nedic Erjavec G, Dodig Curkovic K, Curkovic M, Kovac V, Svob Strac D, Cusek M, Bortolato M, Pivac N. Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males. Biomolecules. 2020; 10(11):1555. https://doi.org/10.3390/biom10111555

Chicago/Turabian Style

Podobnik, Josip; Nikolac Perkovic, Matea; Nedic Erjavec, Gordana; Dodig Curkovic, Katarina; Curkovic, Mario; Kovac, Vlatka; Svob Strac, Dubravka; Cusek, Melita; Bortolato, Marco; Pivac, Nela. 2020. "Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males" Biomolecules 10, no. 11: 1555. https://doi.org/10.3390/biom10111555

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