Potential Roles of O-GlcNAcylation in Primary Cilia- Mediated Energy Metabolism
Abstract
:1. Introduction
1.1. Primary Cilia in Regulating Energy Homeostasis
1.1.1. Hypothalamic Neuronal Cilia Regulate Energy Balance
1.1.2. Primary Cilia Control Energy Homeostasis and Inhibit Adiposeness
1.1.3. Primary Cilia Regulate Pancreatic β-Cell Insulin Secretion to Balance Energy Metabolism
1.2. O-GlcNAc Functions in Maintaining Energy Homeostasis
1.3. The Nutrient Sensor O-GlcNAc Contributes to Primary Ciliary Length Regulation
2. Main Text
2.1. Interplay between Neuronal Primary Cilia and O-GlcNAnac in Regulating Energy Homeostasis in Hypothalamus
2.1.1. Hypothalamic Neurons Regulate Energy Homeostasis
2.1.2. LepR- and IR-Mediated Metabolic Signaling Pathways Control Feeding, Energy and Glucose Homeostasis in the Hypothalamic Neurons
2.1.3. Primary Cilia on the Hypothalamic Neurons are Critical for the Regulation of Energy Homeostasis
2.1.4. O-GlcNAc Regulates Energy Homeostasis in the Hypothalamus
2.1.5. The Potential of O-GlcNAc Involves in the Dysfunction of Primary Ciliary Induced Obesity/Diabetes
2.2. Primary Cilia Inhibit Adipocyte Differentiation to Regulate Energy Homeostasis
2.3. Primary Cilia Regulate Glucose Homeostasis through Function in Pancreatic Development and Insulin Secretion
2.3.1. Primary Cilia Regulate Pancreatic Development
2.3.2. Primary Cilia Regulate Glucose Homeostasis and Insulin Secretion
2.3.3. O-GlcNAc Is Critical for the Pancreatic Development
2.3.4. O-GlcNAc Regulates Glucose Homeostasis and Insulin Secretion of Pancreas
3. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Tian, J.L.; Gomeshtapeh, F.I. Potential Roles of O-GlcNAcylation in Primary Cilia- Mediated Energy Metabolism. Biomolecules 2020, 10, 1504. https://doi.org/10.3390/biom10111504
Tian JL, Gomeshtapeh FI. Potential Roles of O-GlcNAcylation in Primary Cilia- Mediated Energy Metabolism. Biomolecules. 2020; 10(11):1504. https://doi.org/10.3390/biom10111504
Chicago/Turabian StyleTian, Jie L., and Farzad Islami Gomeshtapeh. 2020. "Potential Roles of O-GlcNAcylation in Primary Cilia- Mediated Energy Metabolism" Biomolecules 10, no. 11: 1504. https://doi.org/10.3390/biom10111504
APA StyleTian, J. L., & Gomeshtapeh, F. I. (2020). Potential Roles of O-GlcNAcylation in Primary Cilia- Mediated Energy Metabolism. Biomolecules, 10(11), 1504. https://doi.org/10.3390/biom10111504