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Article

Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion

1
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112, Taiwan
2
School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
3
Institute of Pharmacology, National Yang-Ming University, Taipei 112, Taiwan
4
Department of Pharmacy, Taipei, Veterans General Hospital, Taipei 112, Taiwan
5
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan
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Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital & Fu-Jen Catholic University, Taipei 24352, Taiwan
7
Department of Ophthalmology, Tri-Service General Hospital & National Defense Medical Center, Taipei 114, Taiwan
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Department of Ophthalmology, Taipei City Hospital, Taipei 103, Taiwan
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Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan
10
Department of Ophthalmology, Chung Shan Medical University Hospital, Taichung 402, Taiwan
11
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
12
Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(10), 1414; https://doi.org/10.3390/biom10101414
Received: 8 September 2020 / Revised: 30 September 2020 / Accepted: 2 October 2020 / Published: 6 October 2020
Objectives: Retinal vein occlusions (RVO) are associated with systemic risk factors. However, the ocular occlusive events might also influence a patient’s systemic condition. This study tried to investigate serum biomarkers associated with oxidative stress, before and after intravitreal anti-vascular endothelial growth factor (aVEGF) therapy in patients with RVOs. Methods: Newly-onset RVO patients were categorized into two groups: comorbid with macular edema requiring aVEGF therapy (treatment group) and no edema (observation group). Age and sex-matched patients (who received cataract surgery) were included as the control group. Intravitreal ranibizumab with a pro-re-nata regimen were administered. Serum samples were collected prior to treatment, at 6 and 12 months after therapy/observation and were collected once before controls who received cataract surgery. mRNA expression of sirtuin-1, its downstream genes, anti-oxidative biomarkers, and proinflammatory cytokines were measured. Results: There were 32, 26, and 34 patients enrolled in the treatment, observation, and control groups, respectively. The expressions of sirtuin-1 and its downstream genes were significantly lower in patients with RVO compared with the control group. Sirtuin-1 gene expression increased after 1 year of aVEGF therapy in the treatment group but remained unchanged in the observation group. Biomarkers of oxidative stress and proinflammatory cytokines were reduced after 1 year of aVEGF therapy. These biomarkers remained with no changes in the observation group. Conclusions: Our study showed that the systemic oxidative stress increased in RVO patients. The aVEGF therapy could alter the gene expression of anti-oxidative proteins and reduce systemic oxidative stress in these patients. View Full-Text
Keywords: RVO; oxidative stress; SIRT1; vascular endothelial growth factor; VEGF RVO; oxidative stress; SIRT1; vascular endothelial growth factor; VEGF
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MDPI and ACS Style

Hwang, D.-K.; Chang, Y.-L.; Lin, T.-C.; Peng, C.-H.; Chien, K.-H.; Tsai, C.-Y.; Chen, S.-J.; Chen, K.-H.; Hsu, M.-Y. Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion. Biomolecules 2020, 10, 1414. https://doi.org/10.3390/biom10101414

AMA Style

Hwang D-K, Chang Y-L, Lin T-C, Peng C-H, Chien K-H, Tsai C-Y, Chen S-J, Chen K-H, Hsu M-Y. Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion. Biomolecules. 2020; 10(10):1414. https://doi.org/10.3390/biom10101414

Chicago/Turabian Style

Hwang, De-Kuang, Yuh-Lih Chang, Tai-Chi Lin, Chi-Hsien Peng, Ke-Hung Chien, Ching-Yao Tsai, Shih-Jen Chen, Kuan-Hsuan Chen, and Min-Yen Hsu. 2020. "Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion" Biomolecules 10, no. 10: 1414. https://doi.org/10.3390/biom10101414

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