Anti-BCMA Immunotoxins: Design, Production, and Preclinical Evaluation
Abstract
:1. Introduction
2. BCMA as Therapeutic Target
3. BCMA-Directed mAb
4. Anti-BCMA Drug Conjugate
5. BCMA Directed CAR-T Cell
6. Anti-BCMA BiTEs
7. Recombinant Immunotoxin
8. RIT Targeting BCMA
9. Anti-BCMA IT with Improved Properties
10. Concluding Remarks
Funding
Acknowledgments
Conflicts of Interest
References
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Immunotoxin | Description | Molecular Weight (kDa) | IC50 in H929 (ng/mL) | In Vivo Efficacy (H929 SC Xenograft) | In Vivo Efficacy (H929 BM Xenograft) | Reference |
---|---|---|---|---|---|---|
LMB 70 | BM306-Fab-LRggs | 72 | 1.1 | Growth Inhibition | Complete Response | [35] |
LMB 107 | BM306-dsFv-PE38 | 62 | 1.1 | Growth Inhibition | ND | [38] |
LMB 75 | BM306-dsFv-LRggs | 48 | 1.3 | Growth Inhibition | Complete Response | [41] |
LMB 162 | BM306-dsFv-ABD-LRggs | 54 | 3.6 | Growth Inhibition | ND | [38] |
LMB 173 | BM306-dsFv-MSA21-LRggs | 58 | 2.4 | ND | ND | [38] |
LMB 92 | BM306-Fab-LO10R456A | 72 | 3.1 | Growth Inhibition | ND | [38] |
LMB 103 | BM306-Fab-T20 | 72 | 6.0 | ND | ND | [38] |
LMB 267 | BM306-Fab-T20 A494R | 72 | 1.1 | ND | Complete Response | [38] |
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Bera, T.K. Anti-BCMA Immunotoxins: Design, Production, and Preclinical Evaluation. Biomolecules 2020, 10, 1387. https://doi.org/10.3390/biom10101387
Bera TK. Anti-BCMA Immunotoxins: Design, Production, and Preclinical Evaluation. Biomolecules. 2020; 10(10):1387. https://doi.org/10.3390/biom10101387
Chicago/Turabian StyleBera, Tapan K. 2020. "Anti-BCMA Immunotoxins: Design, Production, and Preclinical Evaluation" Biomolecules 10, no. 10: 1387. https://doi.org/10.3390/biom10101387