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Open AccessArticle

The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration

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Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City 14080, Mexico
2
School of Engineering and Scienses, Tecnologico de Monterrey, Campus Ciudad de Mexico, Mexico City 14380, Mexico
3
Research Unit on Endocrine and Metabolic Diseases, Hospital Juarez de México, Mexico City 01460, Mexico
4
Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City 14080, Mexico
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Unit Coronary, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City 14080, Mexico
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Unit of the Experimental Medicine, Hospital General de Mexico, Dr. Eduardo Liceaga, Mexico City 06726, Mexico
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(10), 1381; https://doi.org/10.3390/biom10101381
Received: 19 August 2020 / Revised: 10 September 2020 / Accepted: 24 September 2020 / Published: 29 September 2020
(This article belongs to the Special Issue Molecular Biomarkers In Cardiology)
Dyslipidemia has a substantial role in the development of acute coronary syndrome (ACS). Low-density lipoprotein receptor (LDLR) plays a critical role in plasma lipoprotein hemostasis, which is involved in the formation of atherosclerotic plaque. This study aimed to evaluate whether LDLR gene polymorphisms are significantly associated with ACS and the plasma lipids profile. Three LDLR gene polymorphisms located in the UTR′3 region (c.*52 A/G, c.*504 A/G, and c.* 773 A/G) were determined using TaqMan genotyping assays in a group of 618 ACS patients and 666 healthy controls. Plasma lipids profile concentrations were determined by enzymatic/colorimetric assays. Under co-dominant and recessive models, the c.*52 A allele of the c.*52 A/G polymorphism was associated with a higher risk of ACS (OR = 2.02, pCCo-dom = 0.033, and OR = 2.00, pCRes = 0.009, respectively). In the same way, under co-dominant and recessive models, the c.*773 G allele of the c.*773 A/G polymorphism was associated with a high risk of ACS (OR = 2.04, pCCo-dom = 0.027, and OR = 2.01, pCRes = 0.007, respectively). The “AAG” haplotype was associated with a high risk of ACS (OR = 1.22, pC = 0.016). The c.*52 AA genotype showed a lower HDL-C concentration than individuals with the GG genotype. In addition, carriers of c.*773 GG genotype carriers had a lower concentration of the high-density lipoprotein-cholesterol (HDL-C) than subjects with the AA genotype. Our data suggest the association of the LDLRc.*773 A/G and LDLR c.*52 A/G polymorphisms with both the risk of developing ACS and with a lower concentration of HDL-C in the study population. View Full-Text
Keywords: genetics; single nucleotide polymorphism; acute coronary syndrome genetics; single nucleotide polymorphism; acute coronary syndrome
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Vargas-Alarcon, G.; Perez-Mendez, O.; Ramirez-Bello, J.; Posadas-Sanchez, R.; Gonzalez-Pacheco, H.; Escobedo, G.; Nieto-Lima, B.; Carreon-Torres, E.; Fragoso, J.M. The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration. Biomolecules 2020, 10, 1381.

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