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Open AccessArticle

Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals

Department of Life Science, College of Bio-Nano Technology, Gachon University, Seongnam 13120, Korea
Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Korea
College of Korean Medicine, Gachon University, Seongnam 13120, Korea
College of Pharmacy, Pusan National University, Busan 46241, Korea
College of Pharmacy, Sookmyung Women′s University, Seoul 04610, Korea
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 57;
Received: 18 November 2019 / Revised: 23 December 2019 / Accepted: 26 December 2019 / Published: 29 December 2019
To investigate the potential effects of acorn shells on atopic dermatitis (AD), we utilized oxazolone (OX)- or 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesion mouse models. Our research demonstrates that Acorn shell extract (ASE) improved the progression of AD-like lesions, including swelling, which were induced by oxazolone on Balb/c mouse ears. Additionally, ASE significantly decreased the ear thickness (OX: 0.42 ± 0.01 mm, OX-ASE: 0.32 ± 0.02 mm) and epidermal thickness (OX: 75.3 ± 32.6 µm, OX-ASE: 46.1 ± 13.4 µm). The continuous DNCB-induced AD mouse model in SKH-1 hairless mice demonstrated that ASE improved AD-like symptoms, including the recovery of skin barrier dysfunction, Immunoglobulin E hyperproduction (DNCB: 340.1 ± 66.8 ng/mL, DNCB-ASE: 234.8 ± 32.9 ng/mL) and an increase in epidermal thickness (DNCB: 96.4 ± 21.9 µm, DNCB-ASE: 52.4 ± 16.3 µm). In addition, we found that ASE suppressed the levels of AD-involved cytokines, such as Tumor Necrosis Factor α, IL-1β, IL-25 and IL-33 in both animal models. Furthermore, gallic acid and ellagic acid isolated from ASE suppressed β-hexosaminidase release and IL-4 expression in RBL-2H3 cells. The acorn shell and its active phytochemicals have potential as a new remedy for the improvement of atopic dermatitis and other inflammatory diseases. View Full-Text
Keywords: acorn shell; atopic dermatitis; IL-4; gallic acid; ellagic acid acorn shell; atopic dermatitis; IL-4; gallic acid; ellagic acid
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Lee, S.; Jegal, H.; Bong, S.-K.; Yoon, K.-N.; Park, N.-J.; Shin, M.-S.; Yang, M.H.; Kim, Y.K.; Kim, S.-N. Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals. Biomolecules 2020, 10, 57.

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