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Open AccessArticle

Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals

1
Department of Life Science, College of Bio-Nano Technology, Gachon University, Seongnam 13120, Korea
2
Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Korea
3
College of Korean Medicine, Gachon University, Seongnam 13120, Korea
4
College of Pharmacy, Pusan National University, Busan 46241, Korea
5
College of Pharmacy, Sookmyung Women′s University, Seoul 04610, Korea
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 57; https://doi.org/10.3390/biom10010057
Received: 18 November 2019 / Revised: 23 December 2019 / Accepted: 26 December 2019 / Published: 29 December 2019
To investigate the potential effects of acorn shells on atopic dermatitis (AD), we utilized oxazolone (OX)- or 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesion mouse models. Our research demonstrates that Acorn shell extract (ASE) improved the progression of AD-like lesions, including swelling, which were induced by oxazolone on Balb/c mouse ears. Additionally, ASE significantly decreased the ear thickness (OX: 0.42 ± 0.01 mm, OX-ASE: 0.32 ± 0.02 mm) and epidermal thickness (OX: 75.3 ± 32.6 µm, OX-ASE: 46.1 ± 13.4 µm). The continuous DNCB-induced AD mouse model in SKH-1 hairless mice demonstrated that ASE improved AD-like symptoms, including the recovery of skin barrier dysfunction, Immunoglobulin E hyperproduction (DNCB: 340.1 ± 66.8 ng/mL, DNCB-ASE: 234.8 ± 32.9 ng/mL) and an increase in epidermal thickness (DNCB: 96.4 ± 21.9 µm, DNCB-ASE: 52.4 ± 16.3 µm). In addition, we found that ASE suppressed the levels of AD-involved cytokines, such as Tumor Necrosis Factor α, IL-1β, IL-25 and IL-33 in both animal models. Furthermore, gallic acid and ellagic acid isolated from ASE suppressed β-hexosaminidase release and IL-4 expression in RBL-2H3 cells. The acorn shell and its active phytochemicals have potential as a new remedy for the improvement of atopic dermatitis and other inflammatory diseases. View Full-Text
Keywords: acorn shell; atopic dermatitis; IL-4; gallic acid; ellagic acid acorn shell; atopic dermatitis; IL-4; gallic acid; ellagic acid
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Lee, S.; Jegal, H.; Bong, S.-K.; Yoon, K.-N.; Park, N.-J.; Shin, M.-S.; Yang, M.H.; Kim, Y.K.; Kim, S.-N. Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals. Biomolecules 2020, 10, 57.

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