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Elucidating the Binding Mechanism of a Novel Silica-Binding Peptide
Open AccessArticle

Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications

1
Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 30013, Taiwan
2
Research and Development Department, Simpson Biotech Co., Ltd., Taoyuan 333, Taiwan
3
Department of Medical Science, National Tsing Hua University, Hsinchu 30013, Taiwan
4
Industrial Technology Research Institute, Hsinchu 30011, Taiwan
5
Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2020, 10(1), 101; https://doi.org/10.3390/biom10010101 (registering DOI)
Received: 28 November 2019 / Revised: 26 December 2019 / Accepted: 4 January 2020 / Published: 7 January 2020
(This article belongs to the Special Issue Peptides: Molecular and Biotechnological Aspects)
Cosmeceutical peptides have become an important topic in recent decades in both academic and industrial fields. Many natural or synthetic peptides with different biological functions including anti-ageing, anti-oxidation, anti-infection and anti-pigmentation have been developed and commercialized. Current cosmeceutical peptides have already satisfied most market demand, remaining: “cargos carrying skin penetrating peptide with high safety” still an un-met need. To this aim, a cell-penetrating peptide, CPPAIF, which efficiently transported cargos into epithelial cells was exanimated. CPPAIF was evaluated with cell model and 3D skin model following OECD guidelines without using animal models. As a highly stable peptide, CPPAIF neither irritated nor sensitized skin, also did not disrupt skin barrier. In addition, such high safety peptide had anti-inflammation activity without allergic effect. Moreover, cargo carrying activity of CPPAIF was assayed using HaCaT cell model and rapid CPPAIF penetration was observed within 30 min. Finally, CPPAIF possessed transepidermal activity in water in oil formulation without disruption of skin barrier. All evidences indicated that CPPAIF was an ideal choice for skin penetrating and its anti-inflammatory activity could improve skin condition, which made CPPAIF suitable and attractive for novel cosmeceutical product development. View Full-Text
Keywords: cell-penetrating peptides; cosmeceutical peptides; anti-inflammation cell-penetrating peptides; cosmeceutical peptides; anti-inflammation
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Fu, T.-K.; Kuo, P.-H.; Lu, Y.-C.; Lin, H.-N.; Wang, L. .-C.; Lin, Y.-C.; Kao, Y.-C.; Lai, H.-M.; Chang, M. .-T. Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications. Biomolecules 2020, 10, 101.

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