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Open AccessArticle

Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected Pharmaceuticals

1
Institute for Plasma Research, Gandhinagar, Gujarat 382428, India
2
Laser Spectroscopy Research Laboratory, Department of Physics, University of Allahabad, Prayagraj 211002, India
3
CMP Degree College, Department of Physics, University of Allahabad, Pragyagraj 211002, India
4
Physics and Astronomy Department, University of Tennessee, University of Tennessee Space Institute, Center for Laser Applications, 411 B.H. Goethert Parkway, Tullahoma, TN 37388-9700, USA
*
Author to whom correspondence should be addressed.
Atoms 2019, 7(3), 71; https://doi.org/10.3390/atoms7030071
Received: 10 June 2019 / Revised: 10 July 2019 / Accepted: 10 July 2019 / Published: 19 July 2019
(This article belongs to the Special Issue Laser Plasma Spectroscopy Applications)
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Abstract

Laser-induced breakdown spectroscopy (LIBS) of pharmaceutical drugs that contain paracetamol was investigated in air and argon atmospheres. The characteristic neutral and ionic spectral lines of various elements and molecular signatures of CN violet and C2 Swan band systems were observed. The relative hardness of all drug samples was measured as well. Principal component analysis, a multivariate method, was applied in the data analysis for demarcation purposes of the drug samples. The CN violet and C2 Swan spectral radiances were investigated for evaluation of a possible correlation of the chemical and molecular structures of the pharmaceuticals. Complementary Raman and Fourier-transform-infrared spectroscopies were used to record the molecular spectra of the drug samples. The application of the above techniques for drug screening are important for the identification and mitigation of drugs that contain additives that may cause adverse side-effects. View Full-Text
Keywords: paracetamol; laser-induced breakdown spectroscopy; cyanide; carbon swan bands; principal component analysis; Raman spectroscopy; Fourier-transform-infrared spectroscopy paracetamol; laser-induced breakdown spectroscopy; cyanide; carbon swan bands; principal component analysis; Raman spectroscopy; Fourier-transform-infrared spectroscopy
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Tiwari, P.K.; Rai, N.K.; Kumar, R.; Parigger, C.G.; Rai, A.K. Atomic and Molecular Laser-Induced Breakdown Spectroscopy of Selected Pharmaceuticals. Atoms 2019, 7, 71.

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