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Urate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort

1
Department of Epidemiology, Colorado School of Public Health, Anschutz Medical Center, Aurora, CO 80045, USA
2
Lifecourse Epidemiology of Adiposity and Diabetes Center, Anschutz Medical Center, Aurora, CO 80045, USA
3
Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA
4
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48105, USA
5
Program for Diabetes and Obesity, The Saban Research Institute, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA
6
Center for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca 62100, México
7
CONACYT, National Institute of Public Health, Center for Research on Nutrition and Health, Cuernavaca, Morelos 62100, Mexico
8
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48105, USA
*
Author to whom correspondence should be addressed.
Metabolites 2019, 9(5), 100; https://doi.org/10.3390/metabo9050100
Received: 5 March 2019 / Revised: 14 May 2019 / Accepted: 15 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Metabolomics in Epidemiological Studies)
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Abstract

We sought to identify metabolites that mark the relationship of sugar-sweetened beverage (SSB) intake with adiposity and metabolic risk among boys (n = 114) and girls (n = 128) aged 8–14 years. We conducted the analysis in three steps: (1) linear regression to examine associations of SSB intake (quartiles) with adiposity, glycemia, lipids, and blood pressure (BP); (2) least absolute shrinkage and selection operator (LASSO) regression to identify SSB-associated metabolites from an untargeted dataset of 938 metabolites; and (3) linear regression to determine whether SSB-related metabolites are also associated with adiposity and metabolic risk. In girls, SSB intake was associated with marginally higher BP (Q2 vs, Q1: 1.11 [−3.90, 6.13], Q3 vs. Q1: 1.16 [−3.81, 6.13], Q4 vs. Q1: 4.65 [−0.22, 9.53] mmHg systolic blood pressure (SBP); P-trend = 0.07). In boys, SSB intake corresponded with higher C-peptide insulin resistance (Q2 vs. Q1: 0.06 [−0.06, 0.19], Q3 vs. Q1: 0.01 [−0.12, 0.14], Q4 vs. Q1: 0.17 [0.04, 0.30] ng/mL; P-trend = 0.03) and leptin (P-trend = 0.02). LASSO identified 6 annotated metabolites in girls (5-methyl-tetrohydrofolate, phenylephrine, urate, nonanoate, deoxyuridine, sn-glycero-3-phosphocholine) and 3 annotated metabolites in boys (2-piperidinone, octanoylcarnitine, catechol) associated with SSB intake. Among girls, urate and nonanoate marked the relationship of SSB intake with BP. None of the SSB-associated metabolites were related to health outcomes in boys. View Full-Text
Keywords: sugar-sweetened beverages; adolescents; metabolomics; LASSO; metabolic risk; blood pressure; uric acid; urate; nonanoate sugar-sweetened beverages; adolescents; metabolomics; LASSO; metabolic risk; blood pressure; uric acid; urate; nonanoate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Perng, W.; Tang, L.; Song, P.X.K.; Goran, M.; Tellez Rojo, M.M.; Cantoral, A.; Peterson, K.E. Urate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort. Metabolites 2019, 9, 100.

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