Computational Methods for the Discovery of Metabolic Markers of Complex Traits
AbstractMetabolomics uses quantitative analyses of metabolites from tissues or bodily fluids to acquire a functional readout of the physiological state. Complex diseases arise from the influence of multiple factors, such as genetics, environment and lifestyle. Since genes, RNAs and proteins converge onto the terminal downstream metabolome, metabolomics datasets offer a rich source of information in a complex and convoluted presentation. Thus, powerful computational methods capable of deciphering the effects of many upstream influences have become increasingly necessary. In this review, the workflow of metabolic marker discovery is outlined from metabolite extraction to model interpretation and validation. Additionally, current metabolomics research in various complex disease areas is examined to identify gaps and trends in the use of several statistical and computational algorithms. Then, we highlight and discuss three advanced machine-learning algorithms, specifically ensemble learning, artificial neural networks, and genetic programming, that are currently less visible, but are budding with high potential for utility in metabolomics research. With an upward trend in the use of highly-accurate, multivariate models in the metabolomics literature, diagnostic biomarker panels of complex diseases are more recently achieving accuracies approaching or exceeding traditional diagnostic procedures. This review aims to provide an overview of computational methods in metabolomics and promote the use of up-to-date machine-learning and computational methods by metabolomics researchers. View Full-Text
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Lee, M.Y.; Hu, T. Computational Methods for the Discovery of Metabolic Markers of Complex Traits. Metabolites 2019, 9, 66.
Lee MY, Hu T. Computational Methods for the Discovery of Metabolic Markers of Complex Traits. Metabolites. 2019; 9(4):66.Chicago/Turabian Style
Lee, Michael Y.; Hu, Ting. 2019. "Computational Methods for the Discovery of Metabolic Markers of Complex Traits." Metabolites 9, no. 4: 66.
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