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Metabolites 2017, 7(4), 56;

An Overview of the Bacterial Carbonic Anhydrases

Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Polo Scientifico, Via U. Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
Istituto di Bioscienze e Biorisorse (IBBR), Consiglio Nazionale delle Ricerche (CNR), via Pietro Castellino 111, 80131 Napoli, Italy
Authors to whom correspondence should be addressed.
Received: 25 October 2017 / Revised: 8 November 2017 / Accepted: 8 November 2017 / Published: 11 November 2017
(This article belongs to the Special Issue Carbonic Anhydrases and Metabolism)
PDF [5728 KB, uploaded 11 November 2017]


Bacteria encode carbonic anhydrases (CAs, EC belonging to three different genetic families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological processes of these organisms. The detailed investigations of many such enzymes from pathogenic and non-pathogenic bacteria afford the opportunity to design both novel therapeutic agents, as well as biomimetic processes, for example, for CO2 capture. Investigation of bacterial CA inhibitors and activators may be relevant for finding antibiotics with a new mechanism of action. View Full-Text
Keywords: bacterial carbonic anhydrases; inhibitors; antibiotic; CO2 capture; engineered bacteria bacterial carbonic anhydrases; inhibitors; antibiotic; CO2 capture; engineered bacteria

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Supuran, C.T.; Capasso, C. An Overview of the Bacterial Carbonic Anhydrases. Metabolites 2017, 7, 56.

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