Metabolites 2017, 7(1), 5; https://doi.org/10.3390/metabo7010005
Effects of Different Exercise Modes on the Urinary Metabolic Fingerprint of Men with and without Metabolic Syndrome
Aikaterina Siopi 1,*
, Olga Deda 2, Vasiliki Manou 1
, Spyros Kellis 1, Ioannis Kosmidis 1, Despina Komninou 3, Nikolaos Raikos 4, Kosmas Christoulas 1, Georgios A. Theodoridis 2 and Vassilis Mougios 1
, Spyros Kellis 1, Ioannis Kosmidis 1, Despina Komninou 3, Nikolaos Raikos 4, Kosmas Christoulas 1, Georgios A. Theodoridis 2 and Vassilis Mougios 11
School of Physical Education and Sport Science at Thessaloniki, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
2
School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
3
Department of Nutrition and Dietetics, Alexander Technological Educational Institute of Thessaloniki, 57400 Thessaloniki, Greece
4
Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Meikle
Received: 27 December 2016 / Revised: 20 January 2017 / Accepted: 24 January 2017 / Published: 26 January 2017
(This article belongs to the Special Issue Metabolomics 2016)
Abstract
Exercise is important in the prevention and treatment of the metabolic syndrome (MetS), a cluster of risk factors that raises morbidity. Metabolomics can facilitate the optimization of exercise prescription. This study aimed to investigate whether the response of the human urinary metabolic fingerprint to exercise depends on the presence of MetS or exercise mode. Twenty-three sedentary men (MetS, n = 9, and Healthy, n = 14) completed four trials: resting, high-intensity interval exercise (HIIE), continuous moderate-intensity exercise (CME), and resistance exercise (RE). Urine samples were collected pre-exercise and at 2, 4, and 24 h for targeted analysis by liquid chromatography-mass spectrometry. Time exerted the strongest differentiating effect, followed by exercise mode and health status. The greatest changes were observed in the first post-exercise samples, with a gradual return to baseline at 24 h. RE caused the greatest responses overall, followed by HIIE, while CME had minimal effect. The metabolic fingerprints of the two groups were separated at 2 h, after HIIE and RE; and at 4 h, after HIIE, with evidence of blunted response to exercise in MetS. Our findings show diverse responses of the urinary metabolic fingerprint to different exercise modes in men with and without metabolic syndrome. View Full-TextKeywords:
metabolomics; urinary metabolites; metabolic syndrome; exercise mode
▼
Figures
Graphical abstract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Share & Cite This Article
MDPI and ACS Style
Siopi, A.; Deda, O.; Manou, V.; Kellis, S.; Kosmidis, I.; Komninou, D.; Raikos, N.; Christoulas, K.; Theodoridis, G.A.; Mougios, V. Effects of Different Exercise Modes on the Urinary Metabolic Fingerprint of Men with and without Metabolic Syndrome. Metabolites 2017, 7, 5.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
Metabolites
EISSN 2218-1989
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert