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Metabolites
Volume 15
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Article

Flavonoids and Sesquiterpene Lactones from Lychnophora ericoides (Arnica-Do-Cerrado) and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia

by
Calisto Moreno Cardenas
1,2,
Ren Ove Kratzert
1,
Sofie Hanifle
3,4,
Elida Cleyse Gomes da Mata Kanzaki
5,
Isamu Kanzaki
5,
Brigitte Kircher
3,4 and
Serhat Sezai Çiçek
1,2,*
1
Department of Pharmaceutical Biology, Kiel University, Gutenbergstraße 76, 24118 Kiel, Germany
2
Department of Biotechnology, Hamburg University of Applied Sciences, Ulmenliet 20, 21033 Hamburg, Germany
3
Department of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria
4
Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria
5
Laboratory of Bioprospection, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, DF, Brazil
*
Author to whom correspondence should be addressed.
Metabolites 2025, 15(8), 542; https://doi.org/10.3390/metabo15080542 (registering DOI)
Submission received: 14 July 2025 / Revised: 3 August 2025 / Accepted: 8 August 2025 / Published: 9 August 2025
(This article belongs to the Special Issue Effects of Secondary Plant Metabolites on Human Health)
Review Reports Versions Notes

Abstract

Objectives: Multiple myeloma and acute myeloid leukemia are severe forms of blood cancer, which lack effective therapies for treatment. In our search for new chemical lead structures from nature, we were investigating the Brazilian medicinal plant arnica-do-cerrado (Lychnophora ericoides). Methods: Repeated chromatography led to the isolation of four flavonoids and three sesquiterpenoids, which were evaluated for their cytostatic and cytotoxic properties against HL-60, MOLM-13, AMO-1, and KMS-12 PE cancer cells as well as the non-malignant HS-5 cell line. Results: Whereas the isolated flavonoids displayed only moderate activity, the three sesquiterpene lactones goyazensolide, centratherin, and lychnopholide exhibited pronounced effects against all four tested cell lines. Goyazensolide was the most effective compound, inhibiting proliferation and metabolic activity with IC50 values between 1.0 and 1.6 µM, as well as 1.0 to 2.0 µM, respectively. Centratherin and lychnopholide were somewhat less active but showed higher selectivity towards malignant cell lines, which was most pronounced for MOLM-13 cells. Conclusion: The results of this study revealed interesting natural products that will be further evaluated for their potential as new lead compounds for the treatment of acute myeloid leukemia and multiple myeloma.
Keywords: Lychnophora pinaster; arnica da serra; Cichorioideae; terpene; polyphenol; structure-activity-relationship; cytotoxicity; metabolic activity; hematologic cancer; tumor Lychnophora pinaster; arnica da serra; Cichorioideae; terpene; polyphenol; structure-activity-relationship; cytotoxicity; metabolic activity; hematologic cancer; tumor

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MDPI and ACS Style

Cardenas, C.M.; Kratzert, R.O.; Hanifle, S.; Gomes da Mata Kanzaki, E.C.; Kanzaki, I.; Kircher, B.; Çiçek, S.S. Flavonoids and Sesquiterpene Lactones from Lychnophora ericoides (Arnica-Do-Cerrado) and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia. Metabolites 2025, 15, 542. https://doi.org/10.3390/metabo15080542

AMA Style

Cardenas CM, Kratzert RO, Hanifle S, Gomes da Mata Kanzaki EC, Kanzaki I, Kircher B, Çiçek SS. Flavonoids and Sesquiterpene Lactones from Lychnophora ericoides (Arnica-Do-Cerrado) and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia. Metabolites. 2025; 15(8):542. https://doi.org/10.3390/metabo15080542

Chicago/Turabian Style

Cardenas, Calisto Moreno, Ren Ove Kratzert, Sofie Hanifle, Elida Cleyse Gomes da Mata Kanzaki, Isamu Kanzaki, Brigitte Kircher, and Serhat Sezai Çiçek. 2025. "Flavonoids and Sesquiterpene Lactones from Lychnophora ericoides (Arnica-Do-Cerrado) and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia" Metabolites 15, no. 8: 542. https://doi.org/10.3390/metabo15080542

APA Style

Cardenas, C. M., Kratzert, R. O., Hanifle, S., Gomes da Mata Kanzaki, E. C., Kanzaki, I., Kircher, B., & Çiçek, S. S. (2025). Flavonoids and Sesquiterpene Lactones from Lychnophora ericoides (Arnica-Do-Cerrado) and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia. Metabolites, 15(8), 542. https://doi.org/10.3390/metabo15080542

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