Sex Hormone-Binding Globulin and Metabolic Syndrome in Children and Adolescents: A Focus on Puberty
Abstract
1. Introduction
2. Overview of Sex Hormone-Binding Globulin (SHBG)
3. SHBG Gene Expression
4. Ontogeny of SHBG Production
5. Hormonal and Metabolic Regulation of SHBG Production
6. Direct Effects of SHBG
7. SHBG, a Biomarker of Metabolic Disease in Children and Adolescents
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Decrease | Increase |
---|---|
Androgens | Estrogens |
Obesity | Pregnancy |
Insulin resistance | SERMs * |
Metabolic syndrome | Thinness |
Type 2 diabetes mellitus | Weight loss |
Gestational diabetes mellitus | Alcoholic liver disease |
Polycystic ovary syndrome | Hepatitis-B and hepatitis-C infection |
Metabolic fatty liver disease | Hyperthyroidism |
Acromegaly | Thyroid hormone receptor-b agonists |
Cushing syndrome | Growth hormone deficiency |
Congenital adrenal hyperplasia | Hemochromatosis |
Hyperprolactinemia | Acute intermittent porphyria |
Tumor necrosis factor alpha | First generation anticonvulsants |
Interleukin-1 beta | Mitotane |
Genetic polymorphisms | Genetic polymorphisms |
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Aydin, B.; Winters, S.J. Sex Hormone-Binding Globulin and Metabolic Syndrome in Children and Adolescents: A Focus on Puberty. Metabolites 2025, 15, 494. https://doi.org/10.3390/metabo15080494
Aydin B, Winters SJ. Sex Hormone-Binding Globulin and Metabolic Syndrome in Children and Adolescents: A Focus on Puberty. Metabolites. 2025; 15(8):494. https://doi.org/10.3390/metabo15080494
Chicago/Turabian StyleAydin, Banu, and Stephen J. Winters. 2025. "Sex Hormone-Binding Globulin and Metabolic Syndrome in Children and Adolescents: A Focus on Puberty" Metabolites 15, no. 8: 494. https://doi.org/10.3390/metabo15080494
APA StyleAydin, B., & Winters, S. J. (2025). Sex Hormone-Binding Globulin and Metabolic Syndrome in Children and Adolescents: A Focus on Puberty. Metabolites, 15(8), 494. https://doi.org/10.3390/metabo15080494