Next Article in Journal
Cultivation of Fungal Endophytes with Tissue Culture Grapevine Seedlings Reprograms Metabolism by Triggering Defence Responses
Next Article in Special Issue
Vitamins and Celiac Disease: Beyond Vitamin D
Previous Article in Journal
Photosynthetic Activities, Phytohormones, and Secondary Metabolites Induction in Plants by Prevailing Compost Residue
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Metabolites
Volume 14
Issue 8
10.3390/metabo14080401
metabolites-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Changes in Serum Metabolome Following Low-Energy Diet-Induced Weight Loss in Women with Overweight and Prediabetes: A PREVIEW-New Zealand Sub-Study

by
Bárbara Relva
1,
Linda M. Samuelsson
2,
Iola F. Duarte
3,
Ulrike Fasol
4,
Patrick J. B. Edwards
5,
Mikael Fogelholm
6,
Anne Raben
7,8,
Sally D. Poppitt
9,*,† and
Marta P. Silvestre
1,9,10,*,†
1
NOVA Medical School, Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal
2
Smart Foods & Bioproducts Group, AgResearch Ltd., Palmerston North 4442, New Zealand
3
Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal
4
Faculty of Medical and Life Sciences, Furtwangen University, 78054 Villingen-Schwenningen, Germany
5
School of Natural Sciences, Massey University, Palmerston North 4442, New Zealand
6
Department of Food and Nutrition, University of Helsinki, Unioninkatu 44, 00014 Helsinki, Finland
7
Department of Nutrition, Exercise and Sports, University of Copenhagen, Nørre Allé 51, DK-2200 Copenhagen, Denmark
8
Department for Clinical and Translational Research, Copenhagen University Hospital, Steno Diabetes Center Copenhagen, Blegdamsvej 9, DK-2100 Herlev, Denmark
9
Human Nutrition Unit, School of Biological Sciences, Department of Medicine, University of Auckland, 18 Carrick Place, Auckland 1024, New Zealand
10
CINTESIS@RISE, NOVA Medical School, Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal
*
Authors to whom correspondence should be addressed.
†
The authors contributed equally to this work.
Metabolites 2024, 14(8), 401; https://doi.org/10.3390/metabo14080401
Submission received: 13 June 2024 / Revised: 8 July 2024 / Accepted: 16 July 2024 / Published: 24 July 2024
(This article belongs to the Special Issue Diet and Nutrition in Relation to Metabolic Health)
Browse Figure
Versions Notes

Abstract

As obesity develops, metabolic changes increase the risk of non-communicable diseases such as type 2 diabetes (T2D). Weight loss is crucial for improving health in T2D and cardiometabolic conditions. However, weight loss rates vary between individuals, even with identical diets or energy restrictions, highlighting the need to identify markers or predictors of weight loss success to enhance intervention outcomes. Using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics, we investigated the change in serum polar metabolites in 28 women with overweight or obesity and prediabetes who completed an 8-week low-energy diet (LED) as part of the PREVIEW (PREVention of diabetes through lifestyle intervention and population studies in Europe and around the World) clinical trial. We aimed to characterize the metabolic shift in substrate oxidation under fixed energy intake (~4 MJ/day) and its relation to weight loss success. Nine of the thirty-four serum metabolites identified significantly changed during the LED phase: 3-hydroxybutyrate, O-acetylcarnitine, 2-hydroxybutyrate, mannose, dimethyl sulfone and isobutyrate increased, whilst choline, creatine and tyrosine decreased. These results confirmed a shift towards lipid oxidation, but no metabolites predicted the response to the LED-induced weight loss. Further studies in larger populations are required to validate these metabolites as biomarkers of diet exposure.
Keywords: low-energy diet; metabolomics; NMR spectroscopy; obesity; polar metabolites; prediabetes; weight loss low-energy diet; metabolomics; NMR spectroscopy; obesity; polar metabolites; prediabetes; weight loss

Share and Cite

MDPI and ACS Style

Relva, B.; Samuelsson, L.M.; Duarte, I.F.; Fasol, U.; Edwards, P.J.B.; Fogelholm, M.; Raben, A.; Poppitt, S.D.; Silvestre, M.P. Changes in Serum Metabolome Following Low-Energy Diet-Induced Weight Loss in Women with Overweight and Prediabetes: A PREVIEW-New Zealand Sub-Study. Metabolites 2024, 14, 401. https://doi.org/10.3390/metabo14080401

AMA Style

Relva B, Samuelsson LM, Duarte IF, Fasol U, Edwards PJB, Fogelholm M, Raben A, Poppitt SD, Silvestre MP. Changes in Serum Metabolome Following Low-Energy Diet-Induced Weight Loss in Women with Overweight and Prediabetes: A PREVIEW-New Zealand Sub-Study. Metabolites. 2024; 14(8):401. https://doi.org/10.3390/metabo14080401

Chicago/Turabian Style

Relva, Bárbara, Linda M. Samuelsson, Iola F. Duarte, Ulrike Fasol, Patrick J. B. Edwards, Mikael Fogelholm, Anne Raben, Sally D. Poppitt, and Marta P. Silvestre. 2024. "Changes in Serum Metabolome Following Low-Energy Diet-Induced Weight Loss in Women with Overweight and Prediabetes: A PREVIEW-New Zealand Sub-Study" Metabolites 14, no. 8: 401. https://doi.org/10.3390/metabo14080401

APA Style

Relva, B., Samuelsson, L. M., Duarte, I. F., Fasol, U., Edwards, P. J. B., Fogelholm, M., Raben, A., Poppitt, S. D., & Silvestre, M. P. (2024). Changes in Serum Metabolome Following Low-Energy Diet-Induced Weight Loss in Women with Overweight and Prediabetes: A PREVIEW-New Zealand Sub-Study. Metabolites, 14(8), 401. https://doi.org/10.3390/metabo14080401

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop