Next Article in Journal
miR-21/SMAD2 Is Involved in the Decrease in Progesterone Synthesis Caused by Lipopolysaccharide Exposure in Follicular Granulosa Cells of Laying Goose
Next Article in Special Issue
Introduction to the Proteomic Analysis of Placentas with Fetal Growth Restriction and Impaired Lipid Metabolism
Previous Article in Journal
A Novel UHPLC-MS/MS Based Method for Isomeric Separation and Quantitative Determination of Cyanogenic Glycosides in American Elderberry
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Metabolites
Volume 14
Issue 7
10.3390/metabo14070361
metabolites-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes

by
Renata Saucedo
1,
Aldo Ferreira-Hermosillo
1,
Magalhi Robledo-Clemente
2,
Mary Flor Díaz-Velázquez
2 and
Jorge Valencia-Ortega
3,*
1
Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico
2
Hospital de Gineco Obstetricia 3, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico
3
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 11000, Mexico
*
Author to whom correspondence should be addressed.
Metabolites 2024, 14(7), 361; https://doi.org/10.3390/metabo14070361
Submission received: 31 May 2024 / Revised: 21 June 2024 / Accepted: 24 June 2024 / Published: 27 June 2024
(This article belongs to the Special Issue Adipose Tissue, Reproduction and Metabolic Health in Women)
Versions Notes

Abstract

Offspring exposed to gestational diabetes mellitus (GDM) exhibit greater adiposity at birth. This early-life phenotype may increase offspring risk of developing obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease later in life. Infants born to women with GDM have a dysregulation of several hormones, cytokines, and growth factors related to fetal fat mass growth. One of the molecular mechanisms of GDM influencing these factors is epigenetic alterations, such as DNA methylation (DNAm). This review will examine the role of DNAm as a potential biomarker for monitoring fetal growth during pregnancy in women with GDM. This information is relevant since it may provide useful new biomarkers for the diagnosis, prognosis, and treatment of fetal growth and its later-life health consequences.
Keywords: DNA methylation; epigenetics; gestational diabetes; macrosomia; birth weight DNA methylation; epigenetics; gestational diabetes; macrosomia; birth weight

Share and Cite

MDPI and ACS Style

Saucedo, R.; Ferreira-Hermosillo, A.; Robledo-Clemente, M.; Díaz-Velázquez, M.F.; Valencia-Ortega, J. Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes. Metabolites 2024, 14, 361. https://doi.org/10.3390/metabo14070361

AMA Style

Saucedo R, Ferreira-Hermosillo A, Robledo-Clemente M, Díaz-Velázquez MF, Valencia-Ortega J. Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes. Metabolites. 2024; 14(7):361. https://doi.org/10.3390/metabo14070361

Chicago/Turabian Style

Saucedo, Renata, Aldo Ferreira-Hermosillo, Magalhi Robledo-Clemente, Mary Flor Díaz-Velázquez, and Jorge Valencia-Ortega. 2024. "Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes" Metabolites 14, no. 7: 361. https://doi.org/10.3390/metabo14070361

APA Style

Saucedo, R., Ferreira-Hermosillo, A., Robledo-Clemente, M., Díaz-Velázquez, M. F., & Valencia-Ortega, J. (2024). Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes. Metabolites, 14(7), 361. https://doi.org/10.3390/metabo14070361

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop