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Metabolites
Volume 13
Issue 5
10.3390/metabo13050617
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Article

The Impact of Metabolic Syndrome Components on Erectile Function in Patients with Type 2 Diabetes

by
Alexandra Katsimardou
1,*,
Dimitrios Patoulias
1,
Ioanna Zografou
1,
Fotios Siskos
1,
Konstantinos Stavropoulos
1,
Konstantinos Imprialos
1,
Zoi Tegou
1,
Aristi Boulmpou
2,
Vivian Georgopoulou
1,
Nikoleta Hatzipapa
1,
Christodoulos Papadopoulos
2 and
Michael Doumas
1,3
1
2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642 Thessaloniki, Greece
2
3rd Department of Cardiology, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642 Thessaloniki, Greece
3
Veterans Affairs Medical Center, George Washington University, Washington, DC 20422, USA
*
Author to whom correspondence should be addressed.
Metabolites 2023, 13(5), 617; https://doi.org/10.3390/metabo13050617
Submission received: 15 March 2023 / Revised: 31 March 2023 / Accepted: 28 April 2023 / Published: 30 April 2023
(This article belongs to the Special Issue New Therapeutic Targets and Treatment Options in Metabolic Syndrome)
Versions Notes

Abstract

Erectile dysfunction is commonly encountered in diabetic patients and in patients with metabolic syndrome; however, only a few studies have assessed patients with metabolic syndrome and type 2 diabetes mellitus (T2DM) regarding their sexual function. The purpose of this study is to examine the effect of metabolic syndrome and its components on the erectile function of T2DM patients. A cross-sectional study including T2DM patients was conducted from November 2018 until November 2020. Participants were evaluated for the presence of metabolic syndrome and their sexual function was assessed using the International Index of Erectile Function (IIEF) questionnaire. A total of 45 consecutive male patients participated in this study. Metabolic syndrome was diagnosed in 84.4% and erectile dysfunction (ED) in 86.7% of them. Metabolic syndrome was not associated with ED or ED severity. Among metabolic syndrome components, only high-density lipoprotein cholesterol (HDL) was associated with ED [x2 (1, n = 45) = 3.894, p = 0.048; OR = 5.5 (95% CI: 0.890–33.99)] and with the IIEF erectile function scores (median 23 vs. 18, U = 75, p = 0.012). Multiple regression analyses showed that HDL was non-significantly associated with the IIEF erectile function scores. In conclusion, among T2DM patients HDL is associated with ED.
Keywords: erectile dysfunction; sexual dysfunction; type 2 diabetes mellitus; metabolic syndrome; hypertension; obesity; triglycerides; HDL erectile dysfunction; sexual dysfunction; type 2 diabetes mellitus; metabolic syndrome; hypertension; obesity; triglycerides; HDL

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MDPI and ACS Style

Katsimardou, A.; Patoulias, D.; Zografou, I.; Siskos, F.; Stavropoulos, K.; Imprialos, K.; Tegou, Z.; Boulmpou, A.; Georgopoulou, V.; Hatzipapa, N.; et al. The Impact of Metabolic Syndrome Components on Erectile Function in Patients with Type 2 Diabetes. Metabolites 2023, 13, 617. https://doi.org/10.3390/metabo13050617

AMA Style

Katsimardou A, Patoulias D, Zografou I, Siskos F, Stavropoulos K, Imprialos K, Tegou Z, Boulmpou A, Georgopoulou V, Hatzipapa N, et al. The Impact of Metabolic Syndrome Components on Erectile Function in Patients with Type 2 Diabetes. Metabolites. 2023; 13(5):617. https://doi.org/10.3390/metabo13050617

Chicago/Turabian Style

Katsimardou, Alexandra, Dimitrios Patoulias, Ioanna Zografou, Fotios Siskos, Konstantinos Stavropoulos, Konstantinos Imprialos, Zoi Tegou, Aristi Boulmpou, Vivian Georgopoulou, Nikoleta Hatzipapa, and et al. 2023. "The Impact of Metabolic Syndrome Components on Erectile Function in Patients with Type 2 Diabetes" Metabolites 13, no. 5: 617. https://doi.org/10.3390/metabo13050617

APA Style

Katsimardou, A., Patoulias, D., Zografou, I., Siskos, F., Stavropoulos, K., Imprialos, K., Tegou, Z., Boulmpou, A., Georgopoulou, V., Hatzipapa, N., Papadopoulos, C., & Doumas, M. (2023). The Impact of Metabolic Syndrome Components on Erectile Function in Patients with Type 2 Diabetes. Metabolites, 13(5), 617. https://doi.org/10.3390/metabo13050617

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