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Metabolites
Volume 13
Issue 1
10.3390/metabo13010055
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Systematic Review

Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia

by
Robert van Vorstenbosch
1,2,*,†,
Hao Ran Cheng
3,4,†,
Daisy Jonkers
2,3,
John Penders
2,5,
Erik Schoon
4,6,
Ad Masclee
2,3,4,
Frederik-Jan van Schooten
1,2,
Agnieszka Smolinska
1,2,‡ and
Zlatan Mujagic
2,3,‡
1
Department of Pharmacology and Toxicology, Maastricht University, 6227 AP Maastricht, The Netherlands
2
NUTRIM, School of Nutrition & Translational Research in Metabolism, Maastricht University, 6227 AP Maastricht, The Netherlands
3
Division of Gastroenterology-Hepatology, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands
4
GROW, School for Oncology and Developmental Biology, Maastricht University, 6227 AP Maastricht, The Netherlands
5
Department of Medical Microbiology, Infectious Diseases and Infection Prevention, Maastricht University Medical Center, 6227 AP Maastricht, The Netherlands
6
Department of Gastroenterology and Hepatology, Catharina Hospital, 5623 EJ Eindhoven, The Netherlands
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
These authors also contributed equally to this work.
Metabolites 2023, 13(1), 55; https://doi.org/10.3390/metabo13010055
Submission received: 24 November 2022 / Revised: 16 December 2022 / Accepted: 22 December 2022 / Published: 30 December 2022
(This article belongs to the Special Issue Insights into How Gut Microbial Metabolites Regulate Innate Immune Responses)
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Abstract

Colorectal cancer (CRC) has been associated with changes in volatile metabolic profiles in several human biological matrices. This enables its non-invasive detection, but the origin of these volatile organic compounds (VOCs) and their relation to the gut microbiome are not yet fully understood. This systematic review provides an overview of the current understanding of this topic. A systematic search using PubMed, Embase, Medline, Cochrane Library, and the Web of Science according to PRISMA guidelines resulted in seventy-one included studies. In addition, a systematic search was conducted that identified five systematic reviews from which CRC-associated gut microbiota data were extracted. The included studies analyzed VOCs in feces, urine, breath, blood, tissue, and saliva. Eight studies performed microbiota analysis in addition to VOC analysis. The most frequently reported dysregulations over all matrices included short-chain fatty acids, amino acids, proteolytic fermentation products, and products related to the tricarboxylic acid cycle and Warburg metabolism. Many of these dysregulations could be related to the shifts in CRC-associated microbiota, and thus the gut microbiota presumably contributes to the metabolic fingerprint of VOC in CRC. Future research involving VOCs analysis should include simultaneous gut microbiota analysis.
Keywords: colorectal cancer; volatile organic compounds; microbiota colorectal cancer; volatile organic compounds; microbiota

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MDPI and ACS Style

van Vorstenbosch, R.; Cheng, H.R.; Jonkers, D.; Penders, J.; Schoon, E.; Masclee, A.; van Schooten, F.-J.; Smolinska, A.; Mujagic, Z. Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia. Metabolites 2023, 13, 55. https://doi.org/10.3390/metabo13010055

AMA Style

van Vorstenbosch R, Cheng HR, Jonkers D, Penders J, Schoon E, Masclee A, van Schooten F-J, Smolinska A, Mujagic Z. Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia. Metabolites. 2023; 13(1):55. https://doi.org/10.3390/metabo13010055

Chicago/Turabian Style

van Vorstenbosch, Robert, Hao Ran Cheng, Daisy Jonkers, John Penders, Erik Schoon, Ad Masclee, Frederik-Jan van Schooten, Agnieszka Smolinska, and Zlatan Mujagic. 2023. "Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia" Metabolites 13, no. 1: 55. https://doi.org/10.3390/metabo13010055

APA Style

van Vorstenbosch, R., Cheng, H. R., Jonkers, D., Penders, J., Schoon, E., Masclee, A., van Schooten, F.-J., Smolinska, A., & Mujagic, Z. (2023). Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia. Metabolites, 13(1), 55. https://doi.org/10.3390/metabo13010055

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