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Article

Exercise and Interorgan Communication: Short-Term Exercise Training Blunts Differences in Consecutive Daily Urine 1H-NMR Metabolomic Signatures between Physically Active and Inactive Individuals

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Biotechnical Faculty, Department of Animal Science, University of Ljubljana, SI-1000 Ljubljana, Slovenia
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Section of Sport Medicine and Biology of Exercise, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece
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Department of Automation, Biocybernetics and Robotics, Jožef Stefan Institute, SI-1000 Ljubljana, Slovenia
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Faculty of Electrical Engineering, University of Ljubljana, Jamova 2, SI-1000 Ljubljana, Slovenia
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NMR Center, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia
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Faculty of Sports, University of Ljubljana, SI-1000 Ljubljana, Slovenia
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Faculty of Civil and Geodetic Engineering, Institute of Sanitary Engineering, University of Ljubljana, SI-1000 Ljubljana, Slovenia
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Author to whom correspondence should be addressed.
Academic Editor: Satu Pekkala
Metabolites 2022, 12(6), 473; https://doi.org/10.3390/metabo12060473
Received: 6 April 2022 / Revised: 20 May 2022 / Accepted: 20 May 2022 / Published: 24 May 2022
Physical inactivity is a worldwide health problem, an important risk for global mortality and is associated with chronic noncommunicable diseases. The aim of this study was to explore the differences in systemic urine 1H-NMR metabolomes between physically active and inactive healthy young males enrolled in the X-Adapt project in response to controlled exercise (before and after the 3-day exercise testing and 10-day training protocol) in normoxic (21% O2), normobaric (~1000 hPa) and normal-temperature (23 °C) conditions at 1 h of 50% maximal pedaling power output (Wpeak) per day. Interrogation of the exercise database established from past X-Adapt results showed that significant multivariate differences existed in physiological traits between trained and untrained groups before and after training sessions and were mirrored in significant differences in urine pH, salinity, total dissolved solids and conductivity. Cholate, tartrate, cadaverine, lysine and N6-acetyllisine were the most important metabolites distinguishing trained and untrained groups. The relatively little effort of 1 h 50% Wpeak per day invested by the untrained effectively modified their resting urine metabolome into one indistinguishable from the trained group, which hence provides a good basis for the planning of future recommendations for health maintenance in adults, irrespective of the starting fitness value. Finally, the 3-day sessions of morning urine samples represent a good candidate biological matrix for future delineations of active and inactive lifestyles detecting differences unobservable by single-day sampling due to day-to-day variability. View Full-Text
Keywords: exercise; trained; untrained; 1H-NMR metabolomics; human metabolome; JADBio; biomarkers exercise; trained; untrained; 1H-NMR metabolomics; human metabolome; JADBio; biomarkers
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MDPI and ACS Style

Deutsch, L.; Sotiridis, A.; Murovec, B.; Plavec, J.; Mekjavic, I.; Debevec, T.; Stres, B. Exercise and Interorgan Communication: Short-Term Exercise Training Blunts Differences in Consecutive Daily Urine 1H-NMR Metabolomic Signatures between Physically Active and Inactive Individuals. Metabolites 2022, 12, 473. https://doi.org/10.3390/metabo12060473

AMA Style

Deutsch L, Sotiridis A, Murovec B, Plavec J, Mekjavic I, Debevec T, Stres B. Exercise and Interorgan Communication: Short-Term Exercise Training Blunts Differences in Consecutive Daily Urine 1H-NMR Metabolomic Signatures between Physically Active and Inactive Individuals. Metabolites. 2022; 12(6):473. https://doi.org/10.3390/metabo12060473

Chicago/Turabian Style

Deutsch, Leon, Alexandros Sotiridis, Boštjan Murovec, Janez Plavec, Igor Mekjavic, Tadej Debevec, and Blaž Stres. 2022. "Exercise and Interorgan Communication: Short-Term Exercise Training Blunts Differences in Consecutive Daily Urine 1H-NMR Metabolomic Signatures between Physically Active and Inactive Individuals" Metabolites 12, no. 6: 473. https://doi.org/10.3390/metabo12060473

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