Next Article in Journal
Unusual Lipid Components of Legionella gormanii Membranes
Next Article in Special Issue
Ring Trial on Quantitative Assessment of Bile Acids Reveals a Method- and Analyte-Specific Accuracy and Reproducibility
Previous Article in Journal
Low Inflammatory Stimulus Increases D2 Activity and Modulates Thyroid Hormone Metabolism during Myogenesis In Vitro
Previous Article in Special Issue
Evaluation of the Risk of Clostridium difficile Infection Using a Serum Bile Acid Profile
 
 
Article

Metabolic Profile and Metabolite Analyses in Extreme Weight Responders to Gastric Bypass Surgery

1
Department of Endocrinology, Diabetes and Metabolism, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany
2
Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research GmbH-UFZ, Permoserstraße 15, 04318 Leipzig, Germany
3
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Germany
4
Department of Visceral and Metabolic Surgery, University Hospital Leipzig, Liebigstraße 18, 04103 Leipzig, Germany
5
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki, Finland
6
German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Puschstraße 4, 04103 Leipzig, Germany
7
Faculty of Life Sciences, Institute of Biochemistry, University of Leipzig, Brüderstraße 34, 04103 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Phillipe Soucaille
Metabolites 2022, 12(5), 417; https://doi.org/10.3390/metabo12050417
Received: 31 March 2022 / Revised: 26 April 2022 / Accepted: 29 April 2022 / Published: 6 May 2022
(This article belongs to the Special Issue Bile Acid Metabolism and Gut Microbiota)
Background: Roux-en-Y gastric bypass (RYGB) surgery belongs to the most frequently performed surgical therapeutic strategies against adiposity and its comorbidities. However, outcome is limited in a substantial cohort of patients with inadequate primary weight loss or considerable weight regain. In this study, gut microbiota composition and systemically released metabolites were analyzed in a cohort of extreme weight responders after RYGB. Methods: Patients (n = 23) were categorized based on excess weight loss (EWL) at a minimum of two years after RYGB in a good responder (EWL 93 ± 4.3%) or a bad responder group (EWL 19.5 ± 13.3%) for evaluation of differences in metabolic outcome, eating behavior and gut microbiota taxonomy and metabolic activity. Results: Mean BMI was 47.2 ± 6.4 kg/m2 in the bad vs. 26.6 ± 1.2 kg/m2 in the good responder group (p = 0.0001). We found no difference in hunger and satiety sensation, in fasting or postprandial gut hormone release, or in gut microbiota composition between both groups. Differences in weight loss did not reflect in metabolic outcome after RYGB. While fecal and circulating metabolite analyses showed higher levels of propionate (p = 0.0001) in good and valerate (p = 0.04) in bad responders, respectively, conjugated primary and secondary bile acids were higher in good responders in the fasted (p = 0.03) and postprandial state (GCA, p = 0.02; GCDCA, p = 0.02; TCA, p = 0.01; TCDCA, p = 0.02; GDCA, p = 0.05; GUDCA, p = 0.04; TLCA, p = 0.04). Conclusions: Heterogenous weight loss response to RYGB surgery separates from patients’ metabolic outcome, and is linked to unique serum metabolite signatures post intervention. These findings suggest that the level of adiposity reduction alone is insufficient to assess the metabolic success of RYGB surgery, and that longitudinal metabolite profiling may eventually help us to identify markers that could predict individual adiposity response to surgery and guide patient selection and counseling. View Full-Text
Keywords: bile acids; bariatric surgery; Roux-en-Y gastric bypass; weight response; gut microbiota bile acids; bariatric surgery; Roux-en-Y gastric bypass; weight response; gut microbiota
Show Figures

Figure 1

MDPI and ACS Style

Fries, C.M.; Haange, S.-B.; Rolle-Kampczyk, U.; Till, A.; Lammert, M.; Grasser, L.; Medawar, E.; Dietrich, A.; Horstmann, A.; von Bergen, M.; Fenske, W.K. Metabolic Profile and Metabolite Analyses in Extreme Weight Responders to Gastric Bypass Surgery. Metabolites 2022, 12, 417. https://doi.org/10.3390/metabo12050417

AMA Style

Fries CM, Haange S-B, Rolle-Kampczyk U, Till A, Lammert M, Grasser L, Medawar E, Dietrich A, Horstmann A, von Bergen M, Fenske WK. Metabolic Profile and Metabolite Analyses in Extreme Weight Responders to Gastric Bypass Surgery. Metabolites. 2022; 12(5):417. https://doi.org/10.3390/metabo12050417

Chicago/Turabian Style

Fries, Charlotte M., Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Andreas Till, Mathis Lammert, Linda Grasser, Evelyn Medawar, Arne Dietrich, Annette Horstmann, Martin von Bergen, and Wiebke K. Fenske. 2022. "Metabolic Profile and Metabolite Analyses in Extreme Weight Responders to Gastric Bypass Surgery" Metabolites 12, no. 5: 417. https://doi.org/10.3390/metabo12050417

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop