First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. Clinical Samples
2.3. Extraction of SHs from AH and Plasma
2.4. Identification and Quantification of SHs Using LC MS/MS
2.5. Quantification of SHs in AH and Plasma
2.6. Quality Control of MRM Signals to Monitor SHs
2.7. Proteomic Analysis of AH and Plasma
2.8. Statistical Analysis for AH SHs
3. Results
3.1. Assessments toward the Quantification of SHs in AH
3.2. Profiles of SHs in AH
3.3. Comparison of SH Profiles between AH and Plasma
3.4. Abundance Responses of AH SHs to Axial Myopia
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Case Number | Case Group | Age | Gender | Eye | Diopter | Degree of Turbidity | AL (od mm) | AL (os mm) | Correspond Plasma |
---|---|---|---|---|---|---|---|---|---|
20201225P0037 | ARC | 73 | female | od | −3.25DC*177 | C4N4P3 | 22 | 21.8 | yes |
20201225P0002 | ARC | 85 | female | od | −1.50DC*94 | C3N3P2 | 23.27 | 23.24 | yes |
20201225P0005 | ARC | 53 | female | od | −3.75DS − 0.50DC*92 | C2N3P4 | 22.24 | 22.11 | yes |
20201225P0067 | ARC | 79 | male | od | −0.25DS − 0.70DC*5 | C2N3P2 | 23.74 | 23.82 | yes |
20201225P0149 | ARC | 68 | female | os | −0.25DS − 0.60DC*9 | C2N3P2 | 23.07 | 23.05 | yes |
20201225P0041 | ARC | 69 | female | od | −0.25DS − 0.30DC*92 | C3N2P2 | 22.34 | 22.52 | yes |
20201225P0012 | ARC | 84 | male | od | −0.75DC*82 | C3N4P3 | 23.58 | 23.56 | yes |
20201225P0034 | ARC | 77 | male | od | −2.00DS − 2.50DC*48 | C2N3P2 | 24.2 | 23.84 | yes |
20201225P0003 | ARC | 82 | male | od | −2.00DS − 3.00DC*110 | C2N3P2 | 24.11 | 24.29 | yes |
20201225P0152 | ARC | 73 | male | os | +2.00DS − 3.25DC*70 | C4N3P3 | 24.16 | 23.95 | yes |
20201225P0137 | ARC | 91 | male | os | −4.5DC*90 | C4N4P4 | 22.54 | 22.56 | yes |
20201225P0121 | ARC | 65 | female | os | +1.50DC*172 | C3N2P2 | 23 | 23.12 | yes |
20200918P0020 | ARC | 67 | female | od | −0.25DC*132 | C2N2P2 | 24.62 | 24.28 | yes |
20200918P0013 | ARC | 71 | female | od | +0.75DS + 1.00DC*90 | C2N3P2 | 23.4 | 23.66 | yes |
20200918P0030 | ARC | 76 | male | od | −1.50DS − 2.00DC*96 | C3N3P3 | 23.12 | 23.41 | yes |
20200918P0019 | ARC | 73 | male | od | +0.75DS + 1.00DC*180 | C3N3P3 | 24.29 | 24.17 | yes |
20200918P0014 | ARC | 77 | female | os | −0.50DC*15 | C2N3P2 | 23.39 | 23.55 | yes |
20200918P0032 | ARC | 74 | male | od | −1.50DS | C3N3P3 | 23.39 | 23.33 | yes |
20200918P0044 | ARC | 78 | male | od | −0.50DC*135 | C4N4P2 | 23.56 | 23.7 | |
20200918P0046 | ARC | 50 | male | os | −0.75DC*77 | C3N3P3 | 23.33 | 23.58 | |
20201225P0015 | ARC | 61 | female | od | −-0.25DC*50 | C2N3P2 | 22.01 | 22.1 | |
20201225P0147 | ARC | 80 | female | os | −0.25DC*149 | C3N3P2 | 24.6 | 24.72 | |
20201225P0072 | ARC | 69 | female | os | +3.00DS − 3.00DC*25 | C4N4P3 | 24.54 | 24.8 | |
20201225P0140 | ARC | 62 | female | od | +2.00DS | C2N2P2 | 22.56 | 22.61 | |
20201225P0160 | ARC | 61 | male | os | −1.25DC*77 | C2N3P2 | 24.11 | 23.92 | |
20201225P0033 | ARC | 83 | male | os | −2.00DC*85 | C4N3P3 | 23.3 | 23.27 | |
20201225P0043 | ARC | 64 | female | os | −0.75DC*153 | C2N3P2 | 23.66 | 23.63 | |
20201225P0095 | ARC | 66 | male | od | +1.25DS + 0.25DC*75 | C3N3P2 | 23.99 | 23.88 | |
20201225P0009 | ARC | 63 | female | od | +3.00DS | C2N3P2 | 23.74 | 23.32 | |
20201225P0071 | ARC | 80 | male | od | −2.50DC*111 | C2N3P2 | 22.22 | 22.8 | yes |
20201225P0019 | ARC | 55 | female | od | −0.50DC*160 | C4N4P3 | 24.47 | 24.34 | yes |
20201225P0133 | ARC | 79 | female | od | −0.77DC*101 | C2N3P2 | 22.43 | 22.33 | yes |
20201225P0065 | ARC | 59 | male | od | −1.75DS − 0.75DC*85 | C2N2P2 | 23.94 | 23.93 | yes |
20201225P0081 | HM | 27 | male | od | −6.00DS − 2.50DC*5 | 27.99 | 24.48 | yes | |
20201225P0045 | HM | 30 | female | od | −8.37DS − 2.37DC*178 | 27.05 | 26.23 | yes | |
20200918P0015 | HM | 30 | female | od | −7.00DS − 1.25DC*172 | 25.09 | 25.31 | yes | |
20200918P0003 | HM | 27 | male | od | −5.75DS | 26.66 | 26.68 | yes | |
20200918P0037 | HM | 27 | female | od | −5.00DS − 1.25DC*80 | 26.76 | 26.67 | yes | |
20200918P0022 | HM | 36 | female | od | −11.62DS − 1.12DC*16 | 27.2 | 27.34 | yes | |
20200918P0017 | HM | 26 | female | od | −6.12DS − 0.87DC*6 | 25.56 | 25.48 | yes | |
20200918P0048 | HM | 21 | female | od | −7.25DS − 0.87DC*179 | 25.47 | 25.48 | ||
20200918P0043 | HM | 20 | male | od | −14.00DS − 4.50DC*90 | 29.92 | 28.42 | ||
20201225P0029 | HM | 36 | female | od | −7.25DS | 26.92 | 30.27 | ||
20201225P0013 | HM | 30 | female | od | −5.62DS − 0.37DC*51 | 26.16 | 26.01 | ||
20201225P0135 | HM | 25 | female | od | −5.87DS − 1.62DC*175 | 26.51 | 27.07 | ||
20201225P0134 | HM | 23 | female | od | −8.37DS − 1.00DC*4 | 27.86 | 27.77 | ||
20201225P0079 | HM | 45 | female | od | −6.25DS − 3.50DC*176 | 25.73 | 25.58 | ||
20201225P0151 | HM | 36 | male | od | −5.50DS | 26.84 | 26.77 | yes | |
20201225P0083 | HM | 19 | male | od | −5.87DS − 0.37DC*46 | 26 | 26 | yes | |
20201225P0111 | HM | 28 | female | od | −10.50DS | 27.96 | 27.19 | yes | |
20201225P0044 | HM | 31 | female | od | −9.00DS − 5.50DC*180 | 26.95 | 26.98 | yes | |
20201225P0153 | HM | 32 | female | od | −13.50DS | 30.18 | 29.81 | yes | |
20201225P0061 | HM | 24 | female | od | −11.25DS − 1.50DC*10 | 26 | 25.82 | yes | |
20201225P0105 | HM | 25 | female | od | −5.25DS | 26.32 | 26.24 | yes | |
20201225P0008 | HM | 26 | female | od | −6.75DS − 0.25DC*93 | 25.49 | 25.51 | yes | |
20201225P0051 | HM | 39 | female | od | −21.00DS − 3.00DC*10 | 25.79 | 26.35 | yes | |
20201225P0084 | HM | 33 | male | od | −7.00DS | 25.79 | 26.35 | yes | |
20201225P0040 | HM | 18 | male | od | −8.62DS − 1.87DC*180 | 26.66 | 26.73 | yes | |
20201225P0023 | HM | 35 | female | od | −6 | 26 | 26 | yes | |
20201225P0154 | HM | 28 | male | od | −12.50DS − 0.75DC*228 | 28.95 | 28.49 | yes | |
20201225P0128 | HM | 23 | female | od | −10.50DS | 26 | 26 | yes | |
20201225P0062 | HM | 23 | male | od | −12.50DS − 3.50DC*158 | 28.89 | 29.1 | yes | |
20201225P0110 | HM | 23 | female | od | −9.25DS − 0.62DC*2 | 27 | 27.5 | yes | |
20201225P0001 | HM | 28 | female | od | −6.75DS | 25.36 | 25.22 | yes | |
20201225P0122 | HM | 28 | male | od | −10.00DS − 2.50DC*170 | 27.67 | 27.34 | yes | |
20201225P0060 | HM | 19 | male | od | −9.50DS − 1.75DC*180 | 26 | 26 | yes | |
20201225P0119 | HM | 23 | female | od | −10.00DS − 2.00DC*180 | 28.83 | 29.19 | yes | |
20201225P0139 | HM | 26 | male | od | −5.25DS − 2.25DC*174 | 27.13 | 26.98 | yes | |
20201225P0118 | HM | 42 | female | od | −7.62DS − 0.25DC*21 | 26.43 | 26.41 | yes | |
20200918P0021 | HM | 24 | female | od | −7.50DS − 0.50DC*2 | 26 | 26 | yes | |
20200918P0012 | HM | 27 | female | od | −8.12DS − 1.00DC*5 | 26.22 | 25.63 | yes | |
20200918P0008 | HM | 24 | female | od | −6.87DS − 2.87DC*6 | 25.97 | 26.13 | yes | |
20200918P0039 | HM | 27 | female | od | −5.12DS − 0.37DC*39 | 26.18 | 26.11 | yes | |
20200918P0036 | HMC | 51 | female | od | −8.00DS − 0.75DC*110 | C2N3P2 | 26.79 | 26.68 | yes |
20200918P0004 | HMC | 52 | male | od | −16.00DS − 0.75DC*4 | C2N2P2 | 30.61 | 29.17 | yes |
20200918P0035 | HMC | 53 | male | os | −8.50DS − 1.50DC*95 | C2N2P2 | 30.32 | 28.9 | yes |
20200918P0026 | HMC | 53 | male | od | −11.00DS − 2.00DC*70 | C2N3P2 | 28.4 | 27.98 | yes |
20200918P0007 | HMC | 53 | female | od | −7.50DS − 1.00DC*90 | C2N2P2 | 26.8 | 26.22 | yes |
20200918P0018 | HMC | 31 | male | os | −9.25DS | C2N2P1 | 25.95 | 25.89 | yes |
20200918P0011 | HMC | 51 | male | os | −10.00DS − 0.50DC*25 | C4N4P3 | 28.16 | 28.82 | yes |
20200918P0001 | HMC | 46 | female | os | −9.00DS/ − 0.50DC*60 | C2N2P2 | 26.63 | 25.77 | yes |
20200918P0005 | HMC | 50 | female | od | −10.00DS | C2N2P2 | 28.21 | 28.67 | yes |
20200918P0028 | HMC | 42 | male | os | −9.00DS − 0.750DC*25 | C3N2P3 | 25.36 | 27.7 | yes |
20200918P0034 | HMC | 47 | male | os | −11.25DS − 1.50DC*143 | C2N2P2 | 28.9 | 28.15 | yes |
20200918P0038 | HMC | 44 | female | od | −2.75DS | C2N2P2 | 25.89 | 25.7 | yes |
20200918P0002 | HMC | 54 | male | os | −7.75DS − 2.25DC*174 | C2N2P2 | 27.22 | 27.6 | yes |
20200918P0016 | LM | 22 | female | od | −5.87DS − 0.50DC*2 | 25.89 | 25.83 | yes | |
20200918P0047 | LM | 30 | female | od | −5.50DS − 0.25DC*2 | 24.89 | 24.88 | ||
20201225P0066 | LM | 26 | female | od | −4.50DS − 1.00DC*10 | 24.78 | 25.02 | ||
20201225P0014 | LM | 35 | female | od | −4.75DS − 1.12DC*150 | 24.6 | 24.16 | ||
20201225P0097 | LM | 26 | female | od | −7.00DS | 24.45 | 24.46 | ||
20201225P0059 | LM | 34 | male | od | −4.50DS − 0.37DC*136 | 25.32 | 25.37 | ||
20201225P0021 | LM | 30 | female | od | −5.00DS − 1.50DC*60 | 24.96 | 24.4 | ||
20201225P0098 | LM | 27 | female | od | −4.12DS − 0.87DC*13 | 24.91 | 24.38 | ||
20201225P0126 | LM | 24 | female | od | −5.50DS − 1.00DC*175 | 26.08 | 25.83 | ||
20201225P0068 | LM | 26 | female | od | −4.50DS | 25.14 | 25.09 | ||
20201225P0017 | LM | 31 | female | od | −5.25DS | 25.31 | 25.34 | ||
20201225P0082 | LM | 37 | female | od | −3.75DS | 23.99 | 23.93 | ||
20201225P0016 | LM | 18 | female | od | −5.50DS − 1.50DC*2 | 25.72 | 26.12 | ||
20201225P0091 | LM | 26 | female | od | −3.50DS − 1.00DC*171 | 24.08 | 24.65 | yes | |
20201225P0093 | LM | 29 | female | od | −5.50DS − 0.62DC*87 | 25.27 | 25.77 | yes | |
20201225P0094 | LM | 22 | male | od | −7.75DS − 1.25DC*8 | 24.99 | 24.61 | yes | |
20200918P0027 | LM | 33 | female | od | −5.00DS | 23 | 23 | yes | |
20200918P0031 | ARC | 68 | male | od | −0.25DC*45 | C2N3P3 | 23.78 | 23.33 | yes |
20200918P0040 | ARC | 60 | male | os | −0.50DC*50 | C2N2P2 | 24.63 | 24.78 | yes |
20201225P0030 | ARC | 66 | male | od | +0.90DC*104 | C3N3P2 | 24.03 | 23.6 | yes |
20201225P0052 | ARC | 73 | female | od | −0.50DC*86 | C3N4P2 | 22.67 | 22.86 | yes |
20201225P0116 | ARC | 83 | male | os | −1.75DC*91 | C2N3P3 | 23.58 | 23.58 | yes |
20201225P0108 | ARC | 84 | female | od | −1.00DC*133 | C3N4P2 | 22.62 | 22.52 | yes |
20201225P0085 | ARC | 73 | female | od | −1.00DC*78 | C2N3P2 | 22.6 | 22.69 | yes |
20201225P0109 | ARC | 89 | male | od | −1.50DC*78 | C3N3P3 | 24.35 | 24.04 | yes |
20201225P0039 | ARC | 53 | female | os | −0.25DS − 0.34DC*100 | C1N3P3 | 23.9 | 23.66 | yes |
20201225P0022 | ARC | 75 | female | os | +1.25DS + 1.50DC*170 | C2N3P2 | 23.26 | 23.29 | yes |
20201225P0101 | ARC | 65 | male | od | −0.25DS − 0.25DC*67 | C2N4P2 | 23.46 | 23.2 | yes |
20200918P0051 | ARC | 68 | female | od | −1.50DC*45 | C4N4P4 | 23.71 | 23.49 | |
20201225P0115 | ARC | 91 | female | os | −1.50DC*92 | C4N4P4 | 23.44 | 22.95 | |
20201225P0114 | ARC | 82 | female | od | −0.50DC*45 | C4N3P3 | 23.4 | 23.38 | |
20201225P0027 | HM | 28 | female | od | −6.37DS − 0.87DC*2 | 26.64 | 26.56 | ||
20201225P0092 | HM | 27 | male | od | −11.00DS − 3.00DC*5 | 29.61 | 28.36 | ||
20201225P0130 | HM | 31 | female | od | −8.37DS − 1.25DC*2 | 28.64 | 27.67 | ||
20201225P0078 | HM | 21 | male | od | −14.50DS − 0.25DC*7 | 29.32 | 28.78 | ||
20201225P0018 | HM | 26 | female | od | −10.00DS − 0.25DC*25 | 28.38 | 28.17 | ||
20201225P0035 | HM | 23 | male | od | −8.00DS − 3.00DC*175 | 29.12 | 28.76 | yes | |
20200918P0029 | HM | 49 | female | od | −10.25DS | 26 | 26 | yes | |
20200918P0041 | HM | 26 | male | od | −7.50DS − 1.75DC*175 | 27.31 | 27.43 | yes | |
20201225P0049 | HM | 20 | female | od | −7.25DS − 1.25DC*38 | 27.92 | 25.17 | yes | |
20201225P0020 | HM | 39 | female | od | −4.75DS | 26.71 | 26.74 | yes | |
20201225P0090 | HM | 40 | male | od | −4.75DS | 26.49 | 26.67 | yes | |
20201225P0142 | HMC | 58 | male | od | −5.50DS − 0.50DC*90 | C2N2P2 | 25.64 | 25.67 | yes |
20201225P0129 | HMC | 54 | male | od | −4.25DS − 3.00DC*170 | C2N3P3 | 26.53 | 26.15 | yes |
20200918P0045 | HMC | 52 | male | os | −5.00DS | C1N1P4 | 26.74 | 26.51 | |
20200918P0050 | HMC | 72 | female | od | −15.00DS − 0.50DC*85 | C3N4P2 | 29.72 | 26.94 | |
20201225P0155 | HMC | 57 | male | os | −7.00DS − 1.00DC*75 | C2N2P2 | 27.14 | 26.92 | |
20201225P0103 | HMC | 37 | male | od | −25.75DS | C2N2P3 | 33.8 | 25.74 | |
20201225P0031 | HMC | 59 | female | os | −9.25DS − 0.50DC*16 | C3N2P2 | 28 | 29.17 | |
20201225P0024 | HMC | 55 | female | od | −9.00DS − 0.25DC*25 | C3N4P2 | 28.05 | 25.34 | |
20201225P0074 | HMC | 52 | male | od | −8.50DS − 0.75DC 167 | C2N2P2 | 27.75 | 24.6 | |
20201225P0010 | HMC | 41 | male | od | −8.00DS − 1.00DC*5 | C2N2P2 | 26.05 | 26.12 | |
20201225P0146 | HMC | 58 | female | os | −16.00DS − 1.50DC*121 | C2N4P4 | 27.17 | 30.06 | |
20201225P0080 | HMC | 62 | male | os | −7.50DS − 1.00DC*75 | C2N2P2 | 25.79 | 26.32 | |
20201225P0026 | HMC | 68 | female | os | −7.00DS − 1.50DC*175 | C3N2P2 | 27.06 | 25.73 | |
20201225P0050 | HMC | 74 | male | os | −20.00DS − 1.50DC*155 | C2N2P2 | 31.31 | 31.31 | |
20201225P0028 | HMC | 48 | male | os | −14.25DS − 2.25DC*80 | C2N3P2 | 27.42 | 27.48 | |
20201225P0025 | HMC | 76 | female | os | −7.50DS − 0.75DC*80 | C2N2P2 | 27.6 | 28.15 | |
20201225P0100 | HMC | 54 | female | os | −23.00DS | C2N2P2 | 32.49 | 31.5 | yes |
20201225P0124 | HMC | 75 | male | os | −12.00DS − 2.50DC*65 | C3N3P2 | 28.98 | 28.99 | yes |
20201225P0104 | LM | 31 | female | od | −2.75DS | 24.57 | 24.47 | yes | |
20201225P0148 | LM | 27 | female | od | −5.00DS | 25.5 | 25.37 | yes | |
20201225P0141 | LM | 28 | female | od | −5.25DS − 2.00DC*5 | 25.07 | 25.96 | yes | |
20201225P0058 | LM | 24 | male | od | −3.25DS | 25.36 | 25.39 | yes | |
20201225P0159 | LM | 36 | female | od | −5.00DS | 25.61 | 25.47 | yes | |
20201225P0088 | LM | 30 | female | od | −4.75DS | 24.81 | 24.85 | yes | |
20201225P0145 | LM | 23 | female | os | −3.75DS | 25.86 | 25.86 | yes | |
20201225P0158 | LM | 24 | female | od | −5.25DS | 24.41 | 24.51 | yes | |
20201225P0138 | LM | 24 | female | od | −5.00DS | 23 | 23 | yes | |
20200918P0025 | LM | 31 | female | od | −5.25DS − 1.00DC*12 | 24.68 | 24.12 | yes | |
20200918P0006 | HM | 20 | male | od | −10.87DS − 4.37DC*1 | 30.9 | 27.88 | yes | |
20200918P0024 | HMC | 37 | female | od | −23.00DS | C1N1P3 | 32.04 | 30.84 | yes |
20200918P0023 | HMC | 41 | female | od | −25.00DS − 1.50DC*162 | C3N4P2 | 33.64 | 32.41 | yes |
20200918P0033 | HMC | 60 | male | od | −21.50DS | C3N3P2 | 28.68 | 29.31 | |
20200918P0042 | HMC | 49 | female | od | −24.00DS − 2.25DC*135 | C2N2P2 | 32.6 | 31.87 | |
20201225P0069 | HMC | 51 | male | od | −29.00DS | C2N2P2 | 31.48 | 30.97 | |
20201225P0156 | HMC | 53 | female | os | −20.00DS − 1.00DC*70 | C2N2P2 | 31.49 | 31.17 | |
20201225P0064 | HMC | 46 | male | od | −14.00DS | C2N2P2 | 28.8 | 28.56 | |
20201225P0113 | HMC | 58 | female | od | −6.00DS | C3N2P3 | 26.34 | 25.74 | |
20201225P0125 | HMC | 69 | male | os | −8.5DS − 1.50DC*85 | C2N2P2 | 31.42 | 30.18 | |
20201225P0099 | HMC | 54 | male | od | −15.50DS − 1.50DC*20 | C2N3P2 | 25.93 | 25.96 | |
20201225P0004 | HMC | 52 | female | os | −15.00DS − 0.50DC*7 | C2N2P2 | 29.07 | 30.06 | |
20201225P0144 | HMC | 50 | female | os | −3.00DS | C2N3P2 | 26.83 | 26.73 | |
20201225P0057 | HMC | 55 | male | od | −11.00DS | C2N2P2 | 31.18 | 32.42 | |
20201225P0165 | HMC | 63 | male | os | −22.50DS | C5N4P2 | 28.94 | 28.85 |
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Chou, T.; Huang, X.; Liu, J.; Liu, X.; Zeng, K.; Yan, Z.; Mei, S.; Sun, L.; Xi, W.; Ni, J.; et al. First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor. Metabolites 2022, 12, 1220. https://doi.org/10.3390/metabo12121220
Chou T, Huang X, Liu J, Liu X, Zeng K, Yan Z, Mei S, Sun L, Xi W, Ni J, et al. First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor. Metabolites. 2022; 12(12):1220. https://doi.org/10.3390/metabo12121220
Chicago/Turabian StyleChou, Tiansheng, Xiaosheng Huang, Jiawei Liu, Xinhua Liu, Kun Zeng, Zonghui Yan, Shaoyi Mei, Liangnan Sun, Wenqun Xi, Jinglan Ni, and et al. 2022. "First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor" Metabolites 12, no. 12: 1220. https://doi.org/10.3390/metabo12121220