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Metabolic View on Human Healthspan: A Lipidome-Wide Association Study

1
Division of Sports and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Birsstrasse 320B, CH-4052 Basel, Switzerland
2
Metabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Quartier UNIL-CHUV, Rue du Bugnon 19, CH-1005 Lausanne, Switzerland
3
Division of Sports Science, Department of Sport, Exercise and Health, University of Basel, Birsstrasse 320B, CH-4052 Basel, Switzerland
*
Authors to whom correspondence should be addressed.
First authors, equally contributed.
Last authors, equally contributed.
Academic Editor: Amedeo Lonardo
Metabolites 2021, 11(5), 287; https://doi.org/10.3390/metabo11050287
Received: 3 April 2021 / Revised: 23 April 2021 / Accepted: 28 April 2021 / Published: 30 April 2021
(This article belongs to the Section Endocrinology and Clinical Metabolic Research)
As ageing is a major risk factor for the development of non-communicable diseases, extending healthspan has become a medical and societal necessity. Precise lipid phenotyping that captures metabolic individuality could support healthspan extension strategies. This study applied ‘omic-scale lipid profiling to characterise sex-specific age-related differences in the serum lipidome composition of healthy humans. A subset of the COmPLETE-Health study, composed of 73 young (25.2 ± 2.6 years, 43% female) and 77 aged (73.5 ± 2.3 years, 48% female) clinically healthy individuals, was investigated, using an untargeted liquid chromatography high-resolution mass spectrometry approach. Compared to their younger counterparts, aged females and males exhibited significant higher levels in 138 and 107 lipid species representing 15 and 13 distinct subclasses, respectively. Percentage of difference ranged from 5.8% to 61.7% (females) and from 5.3% to 46.0% (males), with sphingolipid and glycerophophospholipid species displaying the greatest amplitudes. Remarkably, specific sphingolipid and glycerophospholipid species, previously described as cardiometabolically favourable, were found elevated in aged individuals. Furthermore, specific ether-glycerophospholipid and lyso-glycerophosphocholine species displayed higher levels in aged females only, revealing a more favourable lipidome evolution in females. Altogether, age determined the circulating lipidome composition, while lipid species analysis revealed additional findings that were not observed at the subclass level. View Full-Text
Keywords: healthspan; healthy population study; metabolic phenotyping; lipidomics; serum lipid signature healthspan; healthy population study; metabolic phenotyping; lipidomics; serum lipid signature
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MDPI and ACS Style

Carrard, J.; Gallart-Ayala, H.; Infanger, D.; Teav, T.; Wagner, J.; Knaier, R.; Colledge, F.; Streese, L.; Königstein, K.; Hinrichs, T.; Hanssen, H.; Ivanisevic, J.; Schmidt-Trucksäss, A. Metabolic View on Human Healthspan: A Lipidome-Wide Association Study. Metabolites 2021, 11, 287. https://doi.org/10.3390/metabo11050287

AMA Style

Carrard J, Gallart-Ayala H, Infanger D, Teav T, Wagner J, Knaier R, Colledge F, Streese L, Königstein K, Hinrichs T, Hanssen H, Ivanisevic J, Schmidt-Trucksäss A. Metabolic View on Human Healthspan: A Lipidome-Wide Association Study. Metabolites. 2021; 11(5):287. https://doi.org/10.3390/metabo11050287

Chicago/Turabian Style

Carrard, Justin, Hector Gallart-Ayala, Denis Infanger, Tony Teav, Jonathan Wagner, Raphael Knaier, Flora Colledge, Lukas Streese, Karsten Königstein, Timo Hinrichs, Henner Hanssen, Julijana Ivanisevic, and Arno Schmidt-Trucksäss. 2021. "Metabolic View on Human Healthspan: A Lipidome-Wide Association Study" Metabolites 11, no. 5: 287. https://doi.org/10.3390/metabo11050287

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