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Molecular Mechanisms Underlying the Relationship between Obesity and Male Infertility

Department of Clinical and Experimental Medicine, University of Catania, 95131 Catania, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Jennifer W. Hill
Metabolites 2021, 11(12), 840; https://doi.org/10.3390/metabo11120840
Received: 7 November 2021 / Revised: 1 December 2021 / Accepted: 2 December 2021 / Published: 4 December 2021
(This article belongs to the Special Issue Metabolism and Reproduction)
In recent decades, the worldwide prevalence of obesity has risen dramatically and is currently estimated to be around 20%. Obesity is linked to an increased risk of comorbidities and premature mortality. Several studies have shown that obesity negatively impacts male fertility through various mechanisms. This review aims to investigate the molecular mechanisms through which obesity impairs male reproduction, including obesity-associated hypogonadism and its effects on spermatogenesis, chronic inflammation, and oxidative stress. Obesity negatively impacts both conventional and biofunctional sperm parameters, and it also induces epigenetic changes that can be transferred to offspring. Moreover, obesity-related diseases are linked to a dysregulation of adipocyte function and micro-environmental inflammatory processes. The dysregulated adipokines significantly influence insulin signaling, and they may also have a detrimental effect on testicular function. Sirtuins can also play an important role in inflammatory and metabolic responses in obese patients. Understanding the molecular mechanisms that are involved in obesity-induced male infertility could increase our ability to identify novel targets for the prevention and treatment of obesity and its related consequences. View Full-Text
Keywords: obesity; male fertility; sperm parameters; adipokines; sirtuins obesity; male fertility; sperm parameters; adipokines; sirtuins
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MDPI and ACS Style

Barbagallo, F.; Condorelli, R.A.; Mongioì, L.M.; Cannarella, R.; Cimino, L.; Magagnini, M.C.; Crafa, A.; La Vignera, S.; Calogero, A.E. Molecular Mechanisms Underlying the Relationship between Obesity and Male Infertility. Metabolites 2021, 11, 840. https://doi.org/10.3390/metabo11120840

AMA Style

Barbagallo F, Condorelli RA, Mongioì LM, Cannarella R, Cimino L, Magagnini MC, Crafa A, La Vignera S, Calogero AE. Molecular Mechanisms Underlying the Relationship between Obesity and Male Infertility. Metabolites. 2021; 11(12):840. https://doi.org/10.3390/metabo11120840

Chicago/Turabian Style

Barbagallo, Federica, Rosita A. Condorelli, Laura M. Mongioì, Rossella Cannarella, Laura Cimino, Maria Cristina Magagnini, Andrea Crafa, Sandro La Vignera, and Aldo E. Calogero. 2021. "Molecular Mechanisms Underlying the Relationship between Obesity and Male Infertility" Metabolites 11, no. 12: 840. https://doi.org/10.3390/metabo11120840

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