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Pharmacological Activity and Phytochemical Profile of Acacia Heartwood Extracts

Department of Forest Products, Faculty of Forestry and Environment, IPB University, Bogor 16680, Indonesia
Department of Chemistry, Faculty of Natural Sciences and Mathematics, IPB University, Bogor 16680, Indonesia
Tropical Biopharmaca Research Center, IPB University, Bogor 16128, Indonesia
Forest Tree Seed Technology Research and Development Institute, Bogor 16001, Indonesia
Author to whom correspondence should be addressed.
Academic Editor: Helen D. Skaltsa
Sci. Pharm. 2021, 89(3), 37;
Received: 8 June 2021 / Revised: 26 July 2021 / Accepted: 29 July 2021 / Published: 4 August 2021
Reactive oxygen species (ROS) are related to several degenerative diseases. In this study, Acacia, a genus with many fast-growing species, was investigated to explore the many phytochemical compounds that are biologically active in processes dealing with ROS-related diseases. This study aimed to select extracts of Acacia heartwood on the basis of their pharmacological and phytochemical profiles and identify their bioactive compounds. Five methanolic extracts from Acacia heartwood were evaluated for their antioxidant activity using three different in vitro assays: toxicity toward Artemia salina and phenolic and polyphenolic content. Multivariate analysis was conducted to select two promising extracts and then their bioactive compounds were identified using liquid chromatography coupled with mass spectrometry. Acacia crassicarpa extracts showed the highest antioxidant activity, as well as phenolic and hydrolyzable tannin contents, but low toxicity. The A. mangium extract exhibited high flavonoid and condensed tannin content, whereas A. decurrrens had the highest toxicity with low antioxidant activity. Pearson’s correlation analysis demonstrated no correlation between antioxidant activity and toxicity. Moreover, the phytochemical profile exhibited an association with pharmacological parameters. Principal component analysis followed by cluster analysis divided the extracts into three clusters. Two heartwood extracts of A. crassicarpa and A. auriculiformis were chosen as the best extracts. Identification showed that these extracts were dominated by phenolic compounds, as well as anthraquinone and xanthone. View Full-Text
Keywords: Acacia; antioxidant; toxicity; phytochemical profile; multivariate analysis Acacia; antioxidant; toxicity; phytochemical profile; multivariate analysis
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MDPI and ACS Style

Prayogo, Y.H.; Syafii, W.; Sari, R.K.; Batubara, I.; Danu. Pharmacological Activity and Phytochemical Profile of Acacia Heartwood Extracts. Sci. Pharm. 2021, 89, 37.

AMA Style

Prayogo YH, Syafii W, Sari RK, Batubara I, Danu. Pharmacological Activity and Phytochemical Profile of Acacia Heartwood Extracts. Scientia Pharmaceutica. 2021; 89(3):37.

Chicago/Turabian Style

Prayogo, Yanico H., Wasrin Syafii, Rita K. Sari, Irmanida Batubara, and Danu. 2021. "Pharmacological Activity and Phytochemical Profile of Acacia Heartwood Extracts" Scientia Pharmaceutica 89, no. 3: 37.

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